Cerebral Infarction Associated with Lupus Anticoagulants — Preliminary Report

Robert G. Hart, Vincent T. Miller, Bruce M. Coull, Vera Bril

Research output: Contribution to journalArticlepeer-review

122 Scopus citations


Hypercoagulability may contribute to stroke in young adults. Lupus anticoagulants (LA) were identified in six patients (4%) of 145 young adults with cerebral infarct ion. The clinical features of the 6 patients in this survey plus an additional patient from another institution with LA-associated stroke are presented. Four had systemic lupus erythematosus and 3 had idiopathic LA; all had mild thrombocytopen ia. In 2 patients, no other conditions associated with stroke were discovered after thorough evaluation. Recurrent arterial thrombosis occurred in 4 of 7 patients during an average of two years of follow-up. Evidence suggests that inhibition of prostacyclin formation may occur with LA, promoting a prothrom-botic state.

Original languageEnglish (US)
Pages (from-to)114-118
Number of pages5
Issue number1
StatePublished - 1984

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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