Centrosome instability: when good centrosomes go bad

John M. Ryniawec, Gregory C. Rogers

Research output: Contribution to journalReview articlepeer-review

Abstract

The centrosome is a tiny cytoplasmic organelle that organizes and constructs massive molecular machines to coordinate diverse cellular processes. Due to its many roles during both interphase and mitosis, maintaining centrosome homeostasis is essential to normal health and development. Centrosome instability, divergence from normal centrosome number and structure, is a common pathognomonic cellular state tightly associated with cancers and other genetic diseases. As novel connections are investigated linking the centrosome to disease, it is critical to understand the breadth of centrosome functions to inspire discovery. In this review, we provide an introduction to normal centrosome function and highlight recent discoveries that link centrosome instability to specific disease states.

Original languageEnglish (US)
Pages (from-to)6775-6795
Number of pages21
JournalCellular and Molecular Life Sciences
Volume78
Issue number21-22
DOIs
StatePublished - Nov 2021

Keywords

  • Centriole
  • Centrosome
  • Microtubule
  • Microtubule-organizing center
  • Mitotic spindle
  • Pericentriolar material

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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