Centromere proteins and chromosome inheritance: A complex affair

Kenneth W. Dobie, Kumar L. Hari, Keith A. Maggert, Gary H. Karpen

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Centromeres and the associated kinetochores are involved in essential aspects of chromosome transmission. Recent advances have included the identification and understanding of proteins that have a pivotal role in centromere structure, kinetochore formation, and the coordination of chromosome inheritance with the cell cycle in several organisms. A picture is beginning to emerge of the centromere-kinetechore as a complex and dynamic structure with conservation of function at the protein level across diverse species.

Original languageEnglish (US)
Pages (from-to)206-217
Number of pages12
JournalCurrent Opinion in Genetics and Development
Issue number2
StatePublished - Apr 1999
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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