TY - JOUR
T1 - Central neurons are depressed by iontophoretic and micropressure application of ethanol and tetrahydropapaveroline
AU - Siggins, George R.
AU - French, Edward
N1 - Funding Information:
We thank Drs. Floyd Bloom and Joseph Rogers for critical evaluation of the manuscript and Nancy Callahan for secretarial skills. This research was supported by grants from NIAAA (AA-03119 and AA-03504).
PY - 1979
Y1 - 1979
N2 - In an attempt to circumvent the complexities of systemically administered ethanol and tetrahydroisoquinolines (TIQs), iontophoresis and micropressure application were used to test these agents in single rat neurons. Alcohol applied by either method depressed cerebellar Purkinje cells in a concentration-dependent, non-specific, local anesthetic-like manner. Tests of tetrahydropapaveroline · HCl (THP) on neurons from three brain areas also showed depression of spontaneous discharge, although, in contrast to ethanol, little or no local anesthetic-like action was observed, and at equivalent ejection currents or pressures, the THP depressions appeared to be more pronounced. The underlying mechanisms for these responses are unknown.
AB - In an attempt to circumvent the complexities of systemically administered ethanol and tetrahydroisoquinolines (TIQs), iontophoresis and micropressure application were used to test these agents in single rat neurons. Alcohol applied by either method depressed cerebellar Purkinje cells in a concentration-dependent, non-specific, local anesthetic-like manner. Tests of tetrahydropapaveroline · HCl (THP) on neurons from three brain areas also showed depression of spontaneous discharge, although, in contrast to ethanol, little or no local anesthetic-like action was observed, and at equivalent ejection currents or pressures, the THP depressions appeared to be more pronounced. The underlying mechanisms for these responses are unknown.
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U2 - 10.1016/0376-8716(79)90004-8
DO - 10.1016/0376-8716(79)90004-8
M3 - Article
C2 - 527479
AN - SCOPUS:0018745821
SN - 0376-8716
VL - 4
SP - 239
EP - 243
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
IS - 3-4
ER -