Central nervous system genomics.

Matthew J. Gallek, Leslie Ritter

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


In the past 25 years, remarkable progress has been made in our understanding of genomics and its influence on central nervous system diseases. In this chapter, common diseases of the central nervous system will be reviewed along with the genomics associated with these diseases. The diseases/injuries that will be investigated include neurovascular disorders such as ischemic stroke, hemorrhagic stroke, subarachnoid hemorrhage, and traumatic brain injury. This chapter will also explore Apolipoprotein E (APOE), a 299-aminoacid protein encoded by the APOE gene, and its associations with many of the previously named diseases. APOE was first tied to the risk of Alzheimer's disease and has since then been investigated in traumatic brain injury and hemorrhagic strokes. In addition, we will discuss the future of genomic research in central nervous system diseases.

Original languageEnglish (US)
Pages (from-to)205-226
Number of pages22
JournalAnnual review of nursing research
StatePublished - 2011

ASJC Scopus subject areas

  • General Medicine


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