Cellular immune modulation after a single high dose of levamisole in patients with carcinoma

Uri H. Lewinski; Giora M. Mavligit; Evan M. Hersh

doi:10.1002/1097-0142(19801115)46:10<2185::AID-CNCR2820461015>3.0.CO;2-5

Cellular immune modulation after a single high dose of levamisole in patients with carcinoma

Uri H. Lewinski, Giora M. Mavligit, Evan M. Hersh

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The effect of a single high dose of Levamisole (200 mg/M²) on delayed‐type hypersensitivity (DTH) in vivo and on lymphocyte blastogenesis to mitogens and antigens in vitro was studied in 26 patients with carcinoma. Similar studies were conducted in 24 control patients. Levamisole had a moderate but significant enhancing effect on DTH to Dermatophytin detectable no earlier than eight hours and still present at 48 hours after the drug administration. A moderate but significant enhancing effect on lymphocyte blastogenesis to mitogens and antigens was also demonstrated during the same time sequence. Further clinical trials with Levamisole should be conducted with more attention paid to schedule of drug administration.

Original language	English (US)
Pages (from-to)	2185-2194
Number of pages	10
Journal	Cancer
Volume	46
Issue number	10
DOIs	https://doi.org/10.1002/1097-0142(19801115)46:10<2185::AID-CNCR2820461015>3.0.CO;2-5
State	Published - Nov 15 1980
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1002/1097-0142(19801115)46:10<2185::AID-CNCR2820461015>3.0.CO;2-5

Cite this

@article{a3386aa7d93841eab8f2cb16daedf233,

title = "Cellular immune modulation after a single high dose of levamisole in patients with carcinoma",

abstract = "The effect of a single high dose of Levamisole (200 mg/M2) on delayed‐type hypersensitivity (DTH) in vivo and on lymphocyte blastogenesis to mitogens and antigens in vitro was studied in 26 patients with carcinoma. Similar studies were conducted in 24 control patients. Levamisole had a moderate but significant enhancing effect on DTH to Dermatophytin detectable no earlier than eight hours and still present at 48 hours after the drug administration. A moderate but significant enhancing effect on lymphocyte blastogenesis to mitogens and antigens was also demonstrated during the same time sequence. Further clinical trials with Levamisole should be conducted with more attention paid to schedule of drug administration.",

author = "Lewinski, {Uri H.} and Mavligit, {Giora M.} and Hersh, {Evan M.}",

year = "1980",

month = nov,

day = "15",

doi = "10.1002/1097-0142(19801115)46:10<2185::AID-CNCR2820461015>3.0.CO;2-5",

language = "English (US)",

volume = "46",

pages = "2185--2194",

journal = "Cancer",

issn = "0008-543X",

publisher = "John Wiley and Sons Inc.",

number = "10",

}

TY - JOUR

T1 - Cellular immune modulation after a single high dose of levamisole in patients with carcinoma

AU - Lewinski, Uri H.

AU - Mavligit, Giora M.

AU - Hersh, Evan M.

PY - 1980/11/15

Y1 - 1980/11/15

N2 - The effect of a single high dose of Levamisole (200 mg/M2) on delayed‐type hypersensitivity (DTH) in vivo and on lymphocyte blastogenesis to mitogens and antigens in vitro was studied in 26 patients with carcinoma. Similar studies were conducted in 24 control patients. Levamisole had a moderate but significant enhancing effect on DTH to Dermatophytin detectable no earlier than eight hours and still present at 48 hours after the drug administration. A moderate but significant enhancing effect on lymphocyte blastogenesis to mitogens and antigens was also demonstrated during the same time sequence. Further clinical trials with Levamisole should be conducted with more attention paid to schedule of drug administration.

AB - The effect of a single high dose of Levamisole (200 mg/M2) on delayed‐type hypersensitivity (DTH) in vivo and on lymphocyte blastogenesis to mitogens and antigens in vitro was studied in 26 patients with carcinoma. Similar studies were conducted in 24 control patients. Levamisole had a moderate but significant enhancing effect on DTH to Dermatophytin detectable no earlier than eight hours and still present at 48 hours after the drug administration. A moderate but significant enhancing effect on lymphocyte blastogenesis to mitogens and antigens was also demonstrated during the same time sequence. Further clinical trials with Levamisole should be conducted with more attention paid to schedule of drug administration.

UR - http://www.scopus.com/inward/record.url?scp=0019157352&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019157352&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19801115)46:10<2185::AID-CNCR2820461015>3.0.CO;2-5

DO - 10.1002/1097-0142(19801115)46:10<2185::AID-CNCR2820461015>3.0.CO;2-5

M3 - Article

C2 - 7427861

AN - SCOPUS:0019157352

SN - 0008-543X

VL - 46

SP - 2185

EP - 2194

JO - Cancer

JF - Cancer

IS - 10

ER -

Cellular immune modulation after a single high dose of levamisole in patients with carcinoma

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this