Abstract
The polyamines are essential for eukaryotic cell growth. One of the most critical effects of polyamines on cell growth is the availability of spermidine for the post-translational modification of eIF-5A. Because hypusine-containing eIF-5A is necessary for cell proliferation, depletion of cellular polyamines suppresses growth by depleting cellular modified eIF-5A content. Excess putrescine accumulations in DH23A/b cells induces apoptosis and suppresses the formation of hypusme-containing eIF-5A. Treatment of DH23A/b cells with diaminoheptane also suppresses modified eIF-5A formation and induces apoptosis. These data suggest that suppression of modified eIF-5A formation may play a role in putrescine-induced apoptosis as well.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 150-156 |
| Number of pages | 7 |
| Journal | NeuroSignals |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1997 |
| Externally published | Yes |
Keywords
- Apoptosis
- Cell growth
- Polyamines
- Putrescine
- eIF-5A
ASJC Scopus subject areas
- Neurology
- Developmental Neuroscience
- Cellular and Molecular Neuroscience
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