Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis

Margaret E. Tome; Eugene W. Gerner

doi:10.1159/000109121

Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis

Margaret E. Tome, Eugene W. Gerner

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The polyamines are essential for eukaryotic cell growth. One of the most critical effects of polyamines on cell growth is the availability of spermidine for the post-translational modification of eIF-5A. Because hypusine-containing eIF-5A is necessary for cell proliferation, depletion of cellular polyamines suppresses growth by depleting cellular modified eIF-5A content. Excess putrescine accumulations in DH23A/b cells induces apoptosis and suppresses the formation of hypusme-containing eIF-5A. Treatment of DH23A/b cells with diaminoheptane also suppresses modified eIF-5A formation and induces apoptosis. These data suggest that suppression of modified eIF-5A formation may play a role in putrescine-induced apoptosis as well.

Original language	English (US)
Pages (from-to)	150-156
Number of pages	7
Journal	NeuroSignals
Volume	6
Issue number	3
DOIs	https://doi.org/10.1159/000109121
State	Published - 1997
Externally published	Yes

Keywords

Apoptosis
Cell growth
Polyamines
Putrescine
eIF-5A

ASJC Scopus subject areas

Neurology
Developmental Neuroscience
Cellular and Molecular Neuroscience

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10.1159/000109121

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abstract = "The polyamines are essential for eukaryotic cell growth. One of the most critical effects of polyamines on cell growth is the availability of spermidine for the post-translational modification of eIF-5A. Because hypusine-containing eIF-5A is necessary for cell proliferation, depletion of cellular polyamines suppresses growth by depleting cellular modified eIF-5A content. Excess putrescine accumulations in DH23A/b cells induces apoptosis and suppresses the formation of hypusme-containing eIF-5A. Treatment of DH23A/b cells with diaminoheptane also suppresses modified eIF-5A formation and induces apoptosis. These data suggest that suppression of modified eIF-5A formation may play a role in putrescine-induced apoptosis as well.",

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AU - Tome, Margaret E.

AU - Gerner, Eugene W.

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AB - The polyamines are essential for eukaryotic cell growth. One of the most critical effects of polyamines on cell growth is the availability of spermidine for the post-translational modification of eIF-5A. Because hypusine-containing eIF-5A is necessary for cell proliferation, depletion of cellular polyamines suppresses growth by depleting cellular modified eIF-5A content. Excess putrescine accumulations in DH23A/b cells induces apoptosis and suppresses the formation of hypusme-containing eIF-5A. Treatment of DH23A/b cells with diaminoheptane also suppresses modified eIF-5A formation and induces apoptosis. These data suggest that suppression of modified eIF-5A formation may play a role in putrescine-induced apoptosis as well.

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KW - Polyamines

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KW - eIF-5A

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Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis

Abstract

Keywords

ASJC Scopus subject areas

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