Cellular and molecular interactions in the development of the Xenopus olfactory system

John O. Reiss; Gail D. Burd

doi:10.1006/scdb.1996.0138

Cellular and molecular interactions in the development of the Xenopus olfactory system

John O. Reiss, Gail D. Burd

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Development of the olfactory system in Xenopus laevis begins during gastrulation, with the induction of olfactory placodes at the rostral edge of the prospective neural plate. Initial placodal induction appears to involve cerberus, a molecule secreted from the involuting anterior endoderm. Possible downstream genes expressed in the anterior neural ridge and sense plate include the transcription factors Pax-6, X-d112, X-d113, and Xotx2. Forebrain development is dependent on the presence of the placode and subsequent innervation by olfactory axons, with the extent of this dependence declining as development advances. During metamorphosis thyroid hormones initiate extensive changes in the olfactory system, including the origins of new regions of the olfactory epithelium and olfactory bulb, and a change in olfactory projection patterns.

Original language	English (US)
Pages (from-to)	171-179
Number of pages	9
Journal	Seminars in Cell and Developmental Biology
Volume	8
Issue number	2
DOIs	https://doi.org/10.1006/scdb.1996.0138
State	Published - Apr 1997

Keywords

Induction
Metamorphosis
Olfaction
Olfactory receptor
Xenopus

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1006/scdb.1996.0138

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title = "Cellular and molecular interactions in the development of the Xenopus olfactory system",

abstract = "Development of the olfactory system in Xenopus laevis begins during gastrulation, with the induction of olfactory placodes at the rostral edge of the prospective neural plate. Initial placodal induction appears to involve cerberus, a molecule secreted from the involuting anterior endoderm. Possible downstream genes expressed in the anterior neural ridge and sense plate include the transcription factors Pax-6, X-d112, X-d113, and Xotx2. Forebrain development is dependent on the presence of the placode and subsequent innervation by olfactory axons, with the extent of this dependence declining as development advances. During metamorphosis thyroid hormones initiate extensive changes in the olfactory system, including the origins of new regions of the olfactory epithelium and olfactory bulb, and a change in olfactory projection patterns.",

keywords = "Induction, Metamorphosis, Olfaction, Olfactory receptor, Xenopus",

author = "Reiss, {John O.} and Burd, {Gail D.}",

note = "Funding Information: We thank Cynthia Gentry and Guihua Zhang for assistance with electron microscopy. Supported by NIDCD grants DC-00189 and DC-00446, the University of Arizona Foundation, and the Office of the Vice President for Research at the University of Arizona.",

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AU - Burd, Gail D.

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KW - Metamorphosis

KW - Olfaction

KW - Olfactory receptor

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Cellular and molecular interactions in the development of the Xenopus olfactory system

Abstract

Keywords

ASJC Scopus subject areas

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