TY - JOUR
T1 - Cell mediated hypersensitivity in guinea pigs infected with Toxoplasma gondii
AU - Ourth, D. D.
AU - Lunde, M. N.
AU - Watson, R. R.
PY - 1976
Y1 - 1976
N2 - This investigation demonstrated delayed hypersensitivity by macrophage migration inhibition (MMI) and skin testing (ST) at 4, 8, 12, and 17 weeks and by lymphocyte transformation (LT) at 4, 12, and 17 weeks after infection of guinea pigs (GP) with Toxoplasma gondii (C 37 strain). MMI and LT were both most pronounced at 4 and 17 weeks post infection. GP immunized with toxoplasmin in complete Freund's adjuvant (CFA) demonstrated positive blast transformation and ST, but GP immunized with phosphate buffered saline in CFA did not. MMI was demonstrated with both immunizing preparations. Positive dye test and indirect hemagglutination test titers from 4 through 17 weeks were found.
AB - This investigation demonstrated delayed hypersensitivity by macrophage migration inhibition (MMI) and skin testing (ST) at 4, 8, 12, and 17 weeks and by lymphocyte transformation (LT) at 4, 12, and 17 weeks after infection of guinea pigs (GP) with Toxoplasma gondii (C 37 strain). MMI and LT were both most pronounced at 4 and 17 weeks post infection. GP immunized with toxoplasmin in complete Freund's adjuvant (CFA) demonstrated positive blast transformation and ST, but GP immunized with phosphate buffered saline in CFA did not. MMI was demonstrated with both immunizing preparations. Positive dye test and indirect hemagglutination test titers from 4 through 17 weeks were found.
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U2 - 10.1016/s0300-872x(76)80041-8
DO - 10.1016/s0300-872x(76)80041-8
M3 - Article
C2 - 134544
AN - SCOPUS:0017227650
SN - 0340-904X
VL - 151
SP - 254
EP - 262
JO - Zeitschrift fur Immunitatsforschung
JF - Zeitschrift fur Immunitatsforschung
IS - 3
ER -