Cell-acquiring fallopian endoscope for detection of ovarian cancer via reflectance imaging, fluorescence imaging and cell collection

Dominique Galvez, Ricky Cordova, Kelli Kiekens, Andrew Rocha, William Drake, Photini Rice, John M. Heusinkveld, Jennifer Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Ovarian cancer is the deadliest gynecological cancer, with most cases of high-grade serous ovarian carcinoma originating as serous tubal intraepithelial carcinoma (STIC) lesions in the fallopian tube epithelium. The Cell-Acquiring Fallopian Endoscope (CAFE) was designed to optically detect these STIC lesions and collect cells from the suspicious site for further analysis. While approximately 0.93 mm in diameter, the CAFE is able to perform multispectral fluorescence imaging (MFI), white light imaging for navigation, and cell collection. Each of these modalities is useful to locating potentially pathological areas. To find these regions, the CAFE looks for alterations of the autofluorescence of the tissue. Upon identification of a potential STIC lesion, a scrape biopsy collects cells from the region of interest. The prototype CAFE achieved an imaging resolution of 88 μm at a 5 mm distance, and 45° full field of view in air. When tested on ex vivo porcine tissue, hemocytometry counts determined that on the order of 105 cells per scrape biopsy could be collected. Current progress on the CAFE includes cell collection testing on ex vivo porcine and human tissue, and improvements in the imaging resolution.

Original languageEnglish (US)
Title of host publicationEndoscopic Microscopy XVIII
EditorsGuillermo J. Tearney, Thomas D. Wang, Melissa J. Suter
ISBN (Electronic)9781510658172
StatePublished - 2023
EventEndoscopic Microscopy XVIII 2023 - San Francisco, United States
Duration: Jan 28 2023Jan 29 2023

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceEndoscopic Microscopy XVIII 2023
Country/TerritoryUnited States
CitySan Francisco


  • cancer screening
  • endoscopic biopsy
  • Fallopian tubes
  • fluorescence imaging
  • microendoscope
  • ovarian cancer

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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