Celiac Sprue in Down's Syndrome: Considerations on a Pathogenetic Link

Thomas V. Nowak, Fayez K. Ghishan, Konrad Schulze‐Delrieu

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The association of celiac disease with Down's syndrome is described in two patients who presented with features of the malabsorption syndrome. The diagnosis was readily made by peroral jejunal mucosal biopsy. Both patients responded clinically to dietary gluten withdrawal and one patient demonstrated a recrudescence of symptoms and reappearance of jejunal mucosal atrophy upon rechallenge with dietary gluten. Genetic considerations in the etiology of both disorders are discussed.

Original languageEnglish (US)
Pages (from-to)280-283
Number of pages4
JournalThe American Journal of Gastroenterology
Issue number5
StatePublished - May 1983

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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