TY - JOUR
T1 - CCR4 + T cell recruitment to the skin in mycosis fungoides
T2 - Potential contributions by thymic stromal lymphopoietin and interleukin-16
AU - Tuzova, Marina
AU - Richmond, Jillian
AU - Wolpowitz, Deon
AU - Curiel-Lewandrowski, Clara
AU - Chaney, Keri
AU - Kupper, Thomas
AU - Cruikshank, William
N1 - Publisher Copyright:
© 2014 Informa UK, Ltd.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Mycosis fungoides (MF) is characterized by skin accumulation of CCR4+CCR7- effector memory T cells; however the mechanism for their recruitment is not clearly identified. Thymic Stromal Lymphopoietin (TSLP) is a keratinocyte-derived cytokine that triggers Th2 immunity and is associated with T cell recruitment to the skin in atopic dermatitis. Interleukin-16 (IL-16) is a chemoattractant and growth factor for CD4+ T cells. We hypothesized that TSLP and IL-16 could contribute to recruitment of malignant T cells in MF. We found elevated TSLP and IL-16 in very early stage patients' plasma and skin biopsies, prior to elevation in CCL22. Both TSLP and IL-16 induced migratory responses of CCR4+TSLPR+CD4+CCR7-CD31+ cells, characteristic of malignant T cells in the skin. Co-stimulation also resulted in significant proliferative responses. We conclude that TSLP and IL-16, expressed at early stages of disease, function to recruit malignant T cells to the skin and contribute to their enhanced proliferation.
AB - Mycosis fungoides (MF) is characterized by skin accumulation of CCR4+CCR7- effector memory T cells; however the mechanism for their recruitment is not clearly identified. Thymic Stromal Lymphopoietin (TSLP) is a keratinocyte-derived cytokine that triggers Th2 immunity and is associated with T cell recruitment to the skin in atopic dermatitis. Interleukin-16 (IL-16) is a chemoattractant and growth factor for CD4+ T cells. We hypothesized that TSLP and IL-16 could contribute to recruitment of malignant T cells in MF. We found elevated TSLP and IL-16 in very early stage patients' plasma and skin biopsies, prior to elevation in CCL22. Both TSLP and IL-16 induced migratory responses of CCR4+TSLPR+CD4+CCR7-CD31+ cells, characteristic of malignant T cells in the skin. Co-stimulation also resulted in significant proliferative responses. We conclude that TSLP and IL-16, expressed at early stages of disease, function to recruit malignant T cells to the skin and contribute to their enhanced proliferation.
KW - Cutaneous T cell lymphoma (CTCL)
KW - Interleukin-16 (IL-16)
KW - Mycosis fungoides (MF)
KW - Thymic stromal lymphopoietin (TSLP)
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UR - http://www.scopus.com/inward/citedby.url?scp=84923854064&partnerID=8YFLogxK
U2 - 10.3109/10428194.2014.919634
DO - 10.3109/10428194.2014.919634
M3 - Article
C2 - 24794807
AN - SCOPUS:84923854064
SN - 1042-8194
VL - 56
SP - 440
EP - 449
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 2
ER -