Cationic phenylene ethynylene polymers and oligomers exhibit efficient antiviral activity

Ying Wang; Taylor D. Canady; Zhijun Zhou; Yanli Tang; Dominique N. Price; David G. Bear; Eva Y. Chi; Kirk S. Schanze; David G. Whitten

doi:10.1021/am200575y

Cationic phenylene ethynylene polymers and oligomers exhibit efficient antiviral activity

Ying Wang, Taylor D. Canady, Zhijun Zhou, Yanli Tang, Dominique N. Price, David G. Bear, Eva Y. Chi, Kirk S. Schanze, David G. Whitten

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

The antiviral activities of poly(phenylene ethynylene) (PPE)-based cationic conjugated polyelectrolytes (CPE) and oligo-phenylene ethynylenes (OPE) were investigated using two model viruses, the T4 and MS2 bacteriophages. Under UV/visible light irradiation, significant antiviral activity was observed for all of the CPEs and OPEs; without irradiation, most of these compounds exhibited high inactivation activity against the MS2 phage and moderate inactivation ability against the T4 phage. Transmission electron microscopy (TEM) and SDS polyacrylamide gel electrophoresis (SDS-PAGE) reveal that the CPEs and OPEs exert their antiviral activity by partial disassembly of the phage particle structure in the dark and photochemical damage of the phage capsid protein under UV/visible light irradiation.

Original language	English (US)
Pages (from-to)	2209-2214
Number of pages	6
Journal	ACS Applied Materials and Interfaces
Volume	3
Issue number	7
DOIs	https://doi.org/10.1021/am200575y
State	Published - Jul 27 2011
Externally published	Yes

Keywords

MS2 phage
T4 phage
antiviral
cationic conjugated polyelectrolytes
cationic oligo-phenylene ethynylenes
photoinduced antimicrobial activity

ASJC Scopus subject areas

General Materials Science

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10.1021/am200575y

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@article{12913dd4709641a8b5e6747413af1d6b,

title = "Cationic phenylene ethynylene polymers and oligomers exhibit efficient antiviral activity",

abstract = "The antiviral activities of poly(phenylene ethynylene) (PPE)-based cationic conjugated polyelectrolytes (CPE) and oligo-phenylene ethynylenes (OPE) were investigated using two model viruses, the T4 and MS2 bacteriophages. Under UV/visible light irradiation, significant antiviral activity was observed for all of the CPEs and OPEs; without irradiation, most of these compounds exhibited high inactivation activity against the MS2 phage and moderate inactivation ability against the T4 phage. Transmission electron microscopy (TEM) and SDS polyacrylamide gel electrophoresis (SDS-PAGE) reveal that the CPEs and OPEs exert their antiviral activity by partial disassembly of the phage particle structure in the dark and photochemical damage of the phage capsid protein under UV/visible light irradiation.",

keywords = "MS2 phage, T4 phage, antiviral, cationic conjugated polyelectrolytes, cationic oligo-phenylene ethynylenes, photoinduced antimicrobial activity",

author = "Ying Wang and Canady, {Taylor D.} and Zhijun Zhou and Yanli Tang and Price, {Dominique N.} and Bear, {David G.} and Chi, {Eva Y.} and Schanze, {Kirk S.} and Whitten, {David G.}",

year = "2011",

month = jul,

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doi = "10.1021/am200575y",

language = "English (US)",

volume = "3",

pages = "2209--2214",

journal = "ACS Applied Materials and Interfaces",

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T1 - Cationic phenylene ethynylene polymers and oligomers exhibit efficient antiviral activity

AU - Wang, Ying

AU - Canady, Taylor D.

AU - Zhou, Zhijun

AU - Tang, Yanli

AU - Price, Dominique N.

AU - Bear, David G.

AU - Chi, Eva Y.

AU - Schanze, Kirk S.

AU - Whitten, David G.

PY - 2011/7/27

Y1 - 2011/7/27

N2 - The antiviral activities of poly(phenylene ethynylene) (PPE)-based cationic conjugated polyelectrolytes (CPE) and oligo-phenylene ethynylenes (OPE) were investigated using two model viruses, the T4 and MS2 bacteriophages. Under UV/visible light irradiation, significant antiviral activity was observed for all of the CPEs and OPEs; without irradiation, most of these compounds exhibited high inactivation activity against the MS2 phage and moderate inactivation ability against the T4 phage. Transmission electron microscopy (TEM) and SDS polyacrylamide gel electrophoresis (SDS-PAGE) reveal that the CPEs and OPEs exert their antiviral activity by partial disassembly of the phage particle structure in the dark and photochemical damage of the phage capsid protein under UV/visible light irradiation.

AB - The antiviral activities of poly(phenylene ethynylene) (PPE)-based cationic conjugated polyelectrolytes (CPE) and oligo-phenylene ethynylenes (OPE) were investigated using two model viruses, the T4 and MS2 bacteriophages. Under UV/visible light irradiation, significant antiviral activity was observed for all of the CPEs and OPEs; without irradiation, most of these compounds exhibited high inactivation activity against the MS2 phage and moderate inactivation ability against the T4 phage. Transmission electron microscopy (TEM) and SDS polyacrylamide gel electrophoresis (SDS-PAGE) reveal that the CPEs and OPEs exert their antiviral activity by partial disassembly of the phage particle structure in the dark and photochemical damage of the phage capsid protein under UV/visible light irradiation.

KW - MS2 phage

KW - T4 phage

KW - antiviral

KW - cationic conjugated polyelectrolytes

KW - cationic oligo-phenylene ethynylenes

KW - photoinduced antimicrobial activity

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U2 - 10.1021/am200575y

DO - 10.1021/am200575y

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AN - SCOPUS:80053627840

SN - 1944-8244

VL - 3

SP - 2209

EP - 2214

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 7

ER -

Cationic phenylene ethynylene polymers and oligomers exhibit efficient antiviral activity

Abstract

Keywords

ASJC Scopus subject areas

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