Catalytic ring expansion adventures

Jon T. Njardarson

doi:10.1055/s-0032-1318326

Catalytic ring expansion adventures

Jon T. Njardarson

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

This account summarizes the Njardarson group ring expansion journey from early vinyl oxirane explorations to the latest vinyl oxetane ring expansion discoveries. The evolution of the program and incredible success of Cu(hfacac)₂ as catalyst is detailed. Application of these new ring expansion reactions to natural product, pharmaceutical and commodity chemical targets is discussed as well as our intriguing mechanistic journey and interesting entry into the world of chiral counterion catalysis.

Original language	English (US)
Article number	ST-2013-A0056-A
Pages (from-to)	787-803
Number of pages	17
Journal	Synlett
Volume	24
Issue number	7
DOIs	https://doi.org/10.1055/s-0032-1318326
State	Published - 2013
Externally published	Yes

Keywords

aziridines
catalysis
oxetanes
oxiranes
ring expansion
strained rings
thiiranes

ASJC Scopus subject areas

Organic Chemistry

Access to Document

10.1055/s-0032-1318326

Cite this

@article{fa89b3a0084348e39e3dee966be42401,

title = "Catalytic ring expansion adventures",

abstract = "This account summarizes the Njardarson group ring expansion journey from early vinyl oxirane explorations to the latest vinyl oxetane ring expansion discoveries. The evolution of the program and incredible success of Cu(hfacac)2 as catalyst is detailed. Application of these new ring expansion reactions to natural product, pharmaceutical and commodity chemical targets is discussed as well as our intriguing mechanistic journey and interesting entry into the world of chiral counterion catalysis.",

keywords = "aziridines, catalysis, oxetanes, oxiranes, ring expansion, strained rings, thiiranes",

author = "Njardarson, {Jon T.}",

year = "2013",

doi = "10.1055/s-0032-1318326",

language = "English (US)",

volume = "24",

pages = "787--803",

journal = "Synlett",

issn = "0936-5214",

publisher = "Georg Thieme Verlag",

number = "7",

}

TY - JOUR

T1 - Catalytic ring expansion adventures

AU - Njardarson, Jon T.

PY - 2013

Y1 - 2013

N2 - This account summarizes the Njardarson group ring expansion journey from early vinyl oxirane explorations to the latest vinyl oxetane ring expansion discoveries. The evolution of the program and incredible success of Cu(hfacac)2 as catalyst is detailed. Application of these new ring expansion reactions to natural product, pharmaceutical and commodity chemical targets is discussed as well as our intriguing mechanistic journey and interesting entry into the world of chiral counterion catalysis.

AB - This account summarizes the Njardarson group ring expansion journey from early vinyl oxirane explorations to the latest vinyl oxetane ring expansion discoveries. The evolution of the program and incredible success of Cu(hfacac)2 as catalyst is detailed. Application of these new ring expansion reactions to natural product, pharmaceutical and commodity chemical targets is discussed as well as our intriguing mechanistic journey and interesting entry into the world of chiral counterion catalysis.

KW - aziridines

KW - catalysis

KW - oxetanes

KW - oxiranes

KW - ring expansion

KW - strained rings

KW - thiiranes

UR - http://www.scopus.com/inward/record.url?scp=84874800530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874800530&partnerID=8YFLogxK

U2 - 10.1055/s-0032-1318326

DO - 10.1055/s-0032-1318326

M3 - Article

AN - SCOPUS:84874800530

SN - 0936-5214

VL - 24

SP - 787

EP - 803

JO - Synlett

JF - Synlett

IS - 7

M1 - ST-2013-A0056-A

ER -

Catalytic ring expansion adventures

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this