Catalytic asymmetric oxa-Michael-Michael cascade for facile construction of chiral chromans via an aminal intermediate

Liansuo Zu, Shilei Zhang, Hexin Xie, Wei Wang

Research output: Contribution to journalArticlepeer-review

139 Scopus citations

Abstract

An unprecedented highly enantioselective cascade oxa-Michael-Michael reaction has been developed. The simple and practical process, efficiently catalyzed by chiral diphenylprolinol TMS ether, affords a powerful access to highly functionalized synthetically useful chiral chromans. Moreover, notably a new activation mode involving an aminal is disclosed for the first time.

Original languageEnglish (US)
Pages (from-to)1627-1630
Number of pages4
JournalOrganic Letters
Volume11
Issue number7
DOIs
StatePublished - Apr 2 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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