Abstract
An unprecedented highly enantioselective cascade oxa-Michael-Michael reaction has been developed. The simple and practical process, efficiently catalyzed by chiral diphenylprolinol TMS ether, affords a powerful access to highly functionalized synthetically useful chiral chromans. Moreover, notably a new activation mode involving an aminal is disclosed for the first time.
Original language | English (US) |
---|---|
Pages (from-to) | 1627-1630 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 11 |
Issue number | 7 |
DOIs | |
State | Published - Apr 2 2009 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry