Catalytic asymmetric Catellani-type reaction: A powerful tool for axial chirality construction

Yue Dong, Renshuai Liu, Wei Wang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

This highlight summarizes a recent development of a catalytic enantioselective Catellani-type reaction for the synthesis of axially chiral biaryls. The chirality induction is solely governed by chiral norbornene ligand in the Pd mediated ortho C–H functionalization and ipso cross-coupling transformation. The preparative power of the methodology is demonstrated as a powerful manifold for the divergent synthesis of structurally diverse axially chiral biaryls and chiral fluorenols.

Original languageEnglish (US)
Pages (from-to)83-85
Number of pages3
JournalGreen Synthesis and Catalysis
Volume1
Issue number2
DOIs
StatePublished - Nov 2020
Externally publishedYes

Keywords

  • Asymmetric Catellani reaction
  • Axially chiral biaryls
  • Cross coupling
  • C–H functionalization
  • Divergent synthesis

ASJC Scopus subject areas

  • Biotechnology
  • Catalysis

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