Catalytic asymmetric α-hydroxyamination of carbonyls with n-hydroxycarbamates becomes greener

Chenguang Yu; Aiguo Song; Fang Zhang; Wei Wang

doi:10.1002/cctc.201402121

Catalytic asymmetric α-hydroxyamination of carbonyls with n-hydroxycarbamates becomes greener

Chenguang Yu
, Aiguo Song
, Fang Zhang
, Wei Wang

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The power of two: A highly enantio- and regioselective aminocatalytic and Lewis acid catalyzed α-hydroxyamination of β-keto esters and 1,3-diketones with N-hydroxycarbamates is realized in "one-pot" under aerobic conditions. The powerful dual catalysis strategy opens opportunities for developing new efficient organic transformations. Cbz=Benzyloxycarbonyl, Boc=tert-butoxycarbonyl.

Original language	English (US)
Pages (from-to)	1863-1865
Number of pages	3
Journal	ChemCatChem
Volume	6
Issue number	7
DOIs	https://doi.org/10.1002/cctc.201402121
State	Published - Jul 2014
Externally published	Yes

Keywords

aldol reaction
dual catalysis
hydroxyamination
organocatalysis
oxidation

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1002/cctc.201402121

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abstract = "The power of two: A highly enantio- and regioselective aminocatalytic and Lewis acid catalyzed α-hydroxyamination of β-keto esters and 1,3-diketones with N-hydroxycarbamates is realized in {"}one-pot{"} under aerobic conditions. The powerful dual catalysis strategy opens opportunities for developing new efficient organic transformations. Cbz=Benzyloxycarbonyl, Boc=tert-butoxycarbonyl.",

keywords = "aldol reaction, dual catalysis, hydroxyamination, organocatalysis, oxidation",

author = "Chenguang Yu and Aiguo Song and Fang Zhang and Wei Wang",

year = "2014",

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pages = "1863--1865",

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T1 - Catalytic asymmetric α-hydroxyamination of carbonyls with n-hydroxycarbamates becomes greener

AU - Yu, Chenguang

AU - Song, Aiguo

AU - Zhang, Fang

AU - Wang, Wei

PY - 2014/7

Y1 - 2014/7

N2 - The power of two: A highly enantio- and regioselective aminocatalytic and Lewis acid catalyzed α-hydroxyamination of β-keto esters and 1,3-diketones with N-hydroxycarbamates is realized in "one-pot" under aerobic conditions. The powerful dual catalysis strategy opens opportunities for developing new efficient organic transformations. Cbz=Benzyloxycarbonyl, Boc=tert-butoxycarbonyl.

AB - The power of two: A highly enantio- and regioselective aminocatalytic and Lewis acid catalyzed α-hydroxyamination of β-keto esters and 1,3-diketones with N-hydroxycarbamates is realized in "one-pot" under aerobic conditions. The powerful dual catalysis strategy opens opportunities for developing new efficient organic transformations. Cbz=Benzyloxycarbonyl, Boc=tert-butoxycarbonyl.

KW - aldol reaction

KW - dual catalysis

KW - hydroxyamination

KW - organocatalysis

KW - oxidation

UR - https://www.scopus.com/pages/publications/84904558128

UR - https://www.scopus.com/pages/publications/84904558128#tab=citedBy

U2 - 10.1002/cctc.201402121

DO - 10.1002/cctc.201402121

M3 - Article

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VL - 6

SP - 1863

EP - 1865

JO - ChemCatChem

JF - ChemCatChem

IS - 7

ER -

Catalytic asymmetric α-hydroxyamination of carbonyls with n-hydroxycarbamates becomes greener

Abstract

Keywords

ASJC Scopus subject areas

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