Catalysis of NO production by a molybdoenzyme model

Jill Murray; Donal Macartney; Gregory R.J. Thatcher

doi:10.1021/ol0165701

Catalysis of NO production by a molybdoenzyme model

Jill Murray
, Donal Macartney
, Gregory R.J. Thatcher

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Figure presented Nitric oxide (NO) is an important biological messenger molecule. Nitrates, including nitroglycerin (GTN), are clinically important vasodilators believed to be biotransformed in vivo to NO, a 3e^- reduction. Molybdenum hydrotris-(3,5-dimethyl-1-pyrazolyl) borate complex (MoTPB) was shown to be an efficient catalyst of GTN degradation, with triphenylphosphine (Ph₃P) acting as reducing cofactor, producing significant amounts of NO. MoTPB/Ph₃P is an excellent enzyme model system, showing the feasibility of nitrate biotransformation mediated by a molybdoenzyme.

Original language	English (US)
Pages (from-to)	3635-3638
Number of pages	4
Journal	Organic Letters
Volume	3
Issue number	23
DOIs	https://doi.org/10.1021/ol0165701
State	Published - Nov 15 2001
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Catalysis of NO production by a molybdoenzyme model",

abstract = "Figure presented Nitric oxide (NO) is an important biological messenger molecule. Nitrates, including nitroglycerin (GTN), are clinically important vasodilators believed to be biotransformed in vivo to NO, a 3e- reduction. Molybdenum hydrotris-(3,5-dimethyl-1-pyrazolyl) borate complex (MoTPB) was shown to be an efficient catalyst of GTN degradation, with triphenylphosphine (Ph3P) acting as reducing cofactor, producing significant amounts of NO. MoTPB/Ph3P is an excellent enzyme model system, showing the feasibility of nitrate biotransformation mediated by a molybdoenzyme.",

author = "Jill Murray and Donal Macartney and Thatcher, \{Gregory R.J.\}",

year = "2001",

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language = "English (US)",

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T1 - Catalysis of NO production by a molybdoenzyme model

AU - Murray, Jill

AU - Macartney, Donal

AU - Thatcher, Gregory R.J.

PY - 2001/11/15

Y1 - 2001/11/15

N2 - Figure presented Nitric oxide (NO) is an important biological messenger molecule. Nitrates, including nitroglycerin (GTN), are clinically important vasodilators believed to be biotransformed in vivo to NO, a 3e- reduction. Molybdenum hydrotris-(3,5-dimethyl-1-pyrazolyl) borate complex (MoTPB) was shown to be an efficient catalyst of GTN degradation, with triphenylphosphine (Ph3P) acting as reducing cofactor, producing significant amounts of NO. MoTPB/Ph3P is an excellent enzyme model system, showing the feasibility of nitrate biotransformation mediated by a molybdoenzyme.

AB - Figure presented Nitric oxide (NO) is an important biological messenger molecule. Nitrates, including nitroglycerin (GTN), are clinically important vasodilators believed to be biotransformed in vivo to NO, a 3e- reduction. Molybdenum hydrotris-(3,5-dimethyl-1-pyrazolyl) borate complex (MoTPB) was shown to be an efficient catalyst of GTN degradation, with triphenylphosphine (Ph3P) acting as reducing cofactor, producing significant amounts of NO. MoTPB/Ph3P is an excellent enzyme model system, showing the feasibility of nitrate biotransformation mediated by a molybdoenzyme.

UR - https://www.scopus.com/pages/publications/0035891628

UR - https://www.scopus.com/pages/publications/0035891628#tab=citedBy

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DO - 10.1021/ol0165701

M3 - Article

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SN - 1523-7060

VL - 3

SP - 3635

EP - 3638

JO - Organic Letters

JF - Organic Letters

IS - 23

ER -

Catalysis of NO production by a molybdoenzyme model

Abstract

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