Figure presented Nitric oxide (NO) is an important biological messenger molecule. Nitrates, including nitroglycerin (GTN), are clinically important vasodilators believed to be biotransformed in vivo to NO, a 3e- reduction. Molybdenum hydrotris-(3,5-dimethyl-1-pyrazolyl) borate complex (MoTPB) was shown to be an efficient catalyst of GTN degradation, with triphenylphosphine (Ph3P) acting as reducing cofactor, producing significant amounts of NO. MoTPB/Ph3P is an excellent enzyme model system, showing the feasibility of nitrate biotransformation mediated by a molybdoenzyme.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry