Catalysis of NO production by a molybdoenzyme model

Jill Murray; Donal Macartney; Gregory R.J. Thatcher

doi:10.1021/ol0165701

Catalysis of NO production by a molybdoenzyme model

Jill Murray, Donal Macartney, Gregory R.J. Thatcher

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10 Scopus citations

Abstract

Figure presented Nitric oxide (NO) is an important biological messenger molecule. Nitrates, including nitroglycerin (GTN), are clinically important vasodilators believed to be biotransformed in vivo to NO, a 3e^- reduction. Molybdenum hydrotris-(3,5-dimethyl-1-pyrazolyl) borate complex (MoTPB) was shown to be an efficient catalyst of GTN degradation, with triphenylphosphine (Ph₃P) acting as reducing cofactor, producing significant amounts of NO. MoTPB/Ph₃P is an excellent enzyme model system, showing the feasibility of nitrate biotransformation mediated by a molybdoenzyme.

Original language	English (US)
Pages (from-to)	3635-3638
Number of pages	4
Journal	Organic Letters
Volume	3
Issue number	23
DOIs	https://doi.org/10.1021/ol0165701
State	Published - Nov 15 2001
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "Figure presented Nitric oxide (NO) is an important biological messenger molecule. Nitrates, including nitroglycerin (GTN), are clinically important vasodilators believed to be biotransformed in vivo to NO, a 3e- reduction. Molybdenum hydrotris-(3,5-dimethyl-1-pyrazolyl) borate complex (MoTPB) was shown to be an efficient catalyst of GTN degradation, with triphenylphosphine (Ph3P) acting as reducing cofactor, producing significant amounts of NO. MoTPB/Ph3P is an excellent enzyme model system, showing the feasibility of nitrate biotransformation mediated by a molybdoenzyme.",

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AU - Macartney, Donal

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N2 - Figure presented Nitric oxide (NO) is an important biological messenger molecule. Nitrates, including nitroglycerin (GTN), are clinically important vasodilators believed to be biotransformed in vivo to NO, a 3e- reduction. Molybdenum hydrotris-(3,5-dimethyl-1-pyrazolyl) borate complex (MoTPB) was shown to be an efficient catalyst of GTN degradation, with triphenylphosphine (Ph3P) acting as reducing cofactor, producing significant amounts of NO. MoTPB/Ph3P is an excellent enzyme model system, showing the feasibility of nitrate biotransformation mediated by a molybdoenzyme.

AB - Figure presented Nitric oxide (NO) is an important biological messenger molecule. Nitrates, including nitroglycerin (GTN), are clinically important vasodilators believed to be biotransformed in vivo to NO, a 3e- reduction. Molybdenum hydrotris-(3,5-dimethyl-1-pyrazolyl) borate complex (MoTPB) was shown to be an efficient catalyst of GTN degradation, with triphenylphosphine (Ph3P) acting as reducing cofactor, producing significant amounts of NO. MoTPB/Ph3P is an excellent enzyme model system, showing the feasibility of nitrate biotransformation mediated by a molybdoenzyme.

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Catalysis of NO production by a molybdoenzyme model

Abstract

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