Catalysis of NO production by a molybdoenzyme model

Jill Murray, Donal Macartney, Gregory R.J. Thatcher

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Figure presented Nitric oxide (NO) is an important biological messenger molecule. Nitrates, including nitroglycerin (GTN), are clinically important vasodilators believed to be biotransformed in vivo to NO, a 3e- reduction. Molybdenum hydrotris-(3,5-dimethyl-1-pyrazolyl) borate complex (MoTPB) was shown to be an efficient catalyst of GTN degradation, with triphenylphosphine (Ph3P) acting as reducing cofactor, producing significant amounts of NO. MoTPB/Ph3P is an excellent enzyme model system, showing the feasibility of nitrate biotransformation mediated by a molybdoenzyme.

Original languageEnglish (US)
Pages (from-to)3635-3638
Number of pages4
JournalOrganic Letters
Volume3
Issue number23
DOIs
StatePublished - Nov 15 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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