Ca2+ and Ba2+ effects on basolateral tetraethylammonium transport in isolated snake renal proximal tubules

Yung Kyu Kim, William H. Dantzler

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Previous work on snake renal tubules suggested that basolateral transport of tetraethylammonium (TEA) is symmetrical. To examine regulation of this transport step more closely, we determined the effects of (1) reductions in the extracellular Ca2+ concentration and basolateral Ca2+ entry, and (2) the presence of extracellular Ba2+ on TEA uptake and efflux across the basolateral membrane of isolated snake renal proximal tubules. Removal of extracellular Ca2+ reduced initial TEA uptake and enhanced TEA efflux. Blocking Ca2+ entry also reduced initial TEA uptake. Extracellular Ba2+ depolarized the basolateral membrane and reduced both TEA uptake and efflux. Inhibition of basolateral TEA uptake with a reduced membrane potential supports previous data indicating that uptake involves potential-driven facilitated diffusion. Inhibition of basolateral TEA efflux by Ba2+ even with a reduced membrane potential not only supports previously obtained data indicating that efflux is not influenced by the potential difference and that basolateral TEA transport is asymmetrical, but also suggests that TEA uptake and efflux may occur by separate pathways.

Original languageEnglish (US)
Pages (from-to)28-33
Number of pages6
JournalPflugers Archiv European Journal of Physiology
Issue number1
StatePublished - 1997


  • Asymmetrical transport
  • Barium
  • Calcium
  • Lanthanum
  • Organic cation transport
  • Thamnophis spp.
  • Verapamil

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)


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