Cascade michael-aldol reactions promoted by hydrogen bonding mediated catalysis

Liansuo Zu, Jian Wang, Hao Li, Hexin Xie, Wei Jiang, Wei Wang

Research output: Contribution to journalArticlepeer-review

260 Scopus citations

Abstract

Highly enantio- and diastereoselective tandem Michael-aldol reactions, efficiently catalyzed by a cinchona alkaloid thiourea via synergistic noncovalent hydrogen-bonding activation of both the Michael donor and acceptor, have been developed. The process affords a powerful means for the construction of versatile chiral thiochromanes with the formation of three stereogenic centers in a one-pot synthesis from simple achiral compounds.

Original languageEnglish (US)
Pages (from-to)1036-1037
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number5
DOIs
StatePublished - Feb 7 2007
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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