Carotid endarterectomy after a completed stroke: Reduction in long-term neurologic deterioration

James L. McCullough, Robert M. Mentzer, P. Kent Harman, Donald L. Kaiser, Irving L. Kron, Ivan K. Crosby

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The merit of carotid endarterectomy for patients who previously have sustained a completed stroke remains controversial. Between January 1976 and December 1983, 118 stroke patients with mild to severe permanent neurologic deficits were evaluated. Fifty-nine patients were managed nonoperatively and 59 operatively. Both cohorts were similar in age and sex distribution, incidence of hypertension (69%), diabetes mellitus (25%), and cardiac disease (39%). In the long-term follow-up (medical cohort average was 44.1 ± 5.0 months; surgical cohort average, 41.8 ± 3.7 months) the overall survival rate was comparable, that is, there were nine medical deaths and eight surgical deaths. However, there was a significant difference in the development of new neurologic deficits. Twelve of the 59 unoperated patients had new neurologic deficits and three patients died at 12, 36, and 48 months as a result of a recurrent stroke. New neurologic deficits developed in only two of the 59 surgical patients and there were no stroke-related deaths. When the cumulative probability of remaining free from recurrent deficits was examined in the surviving patients at 6 years, all of the patients in the operated group remained free from recurrent deficits, whereas only 58% of the patients in the unoperated group were free of new neurologic deficits (p = 0.02). These data suggest that stroke patients with fixed mild to moderate neurologic deficits and with carotid lesions may be protected from recurrent neurologic complications by carotid endarterectomy.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalJournal of vascular surgery
Issue number1
StatePublished - Jan 1985

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine


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