Cardiovascular manifestations in patients with thrombotic thrombocytopenic purpura: A single-center experience

Kaushang Gandhi, Wilbert S. Aronow, Harit Desai, Harshad Amin, Mala Sharma, Hoang M. Lai, Parminder Singh

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Cardiovascularmanifestation in patients with thrombotic thrombocytopenic purpura. Hypothesis: The aim of this study was to investigate the incidence of acute myocardial infarction (AMI), arrhythmias, congestive heart failure, andmortality in patients hospitalized for thrombotic thrombocytopenic purpura (TTP). Methods: Thirty-eight patients (27 women and 11 men), mean age 44 years, were hospitalized with the diagnosis of TTP confirmed by a hematologist.We investigated the incidence of AMI which developed during hospitalization for TTP. AMI was diagnosed by new electrocardiographic changes, increased serum cardiac troponin I levels, and clinical symptomatology. The patientswith AMI were alsomonitored for development of arrhythmias during hospitalization. Results: Of the 38 patients, 8 (21%) developed new Q-wave AMI. There was no significant difference in baseline characteristics between patients who developed AMI and those who did not develop AMI. Of the 8 patients with AMI, 2 (25%) developed atrial fibrillation, 1 (13%) developed atrial flutter, 1 (13%) developed supraventriculartachycardia,and2 (25%) developedcongestiveheart failure.Death occurred in 3 of 8 patients (38%) with AMI and in 1 of 30 patients (3%) without AMI (P < 0.01). Conclusions: New Q-wave AMI developed in 21% of 38 patients hospitalized with TTP. Supraventricular tachyarrhythmias developed in 50% of 8 patients with TTP who developed AMI. Patients hospitalized for TTP should be monitored for adverse cardiac events due to the high incidence of new AMI, supraventricular tachyarrhythmias, and mortality.

Original languageEnglish (US)
Pages (from-to)213-216
Number of pages4
JournalClinical cardiology
Issue number4
StatePublished - Apr 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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