TY - JOUR
T1 - Cardioneuroablation for the management of patients with recurrent vasovagal syncope and symptomatic bradyarrhythmias
T2 - the CNA-FWRD Registry
AU - Aksu, Tolga
AU - Tung, Roderick
AU - De Potter, Tom
AU - Markman, Timothy M.
AU - Santangeli, Pasquale
AU - du Fay de Lavallaz, Jeanne
AU - Winterfield, Jeffrey R.
AU - Baykaner, Tina
AU - Alyesh, Daniel
AU - Joza, Jacqueline E.
AU - Gopinathannair, Rakesh
AU - Badertscher, Patrick
AU - Do, Duc H.
AU - Hussein, Ayman
AU - Osorio, Jose
AU - Dewland, Thomas
AU - Perino, Alexander
AU - Rodgers, Albert J.
AU - DeSimone, Christopher
AU - Alfie, Alberto
AU - Atwater, Brett D.
AU - Singh, David
AU - Kumar, Kapil
AU - Salcedo, Jonathan
AU - Bradfield, Jason S.
AU - Upadhyay, Gaurav
AU - Sood, Nitesh
AU - Sharma, Parikshit S.
AU - Gautam, Sandeep
AU - Kumar, Vineet
AU - Forno, Alexander Romeno Janner Dal
AU - Woods, Christopher E.
AU - Rav-Acha, Moshe
AU - Valeriano, Chiara
AU - Kapur, Sunil
AU - Enriquez, Andres
AU - Sundaram, Sri
AU - Glikson, Michael
AU - Gerstenfeld, Edward
AU - Piccini, Jonathan
AU - Tzou, Wendy S.
AU - Sauer, William
AU - d’Avila, Andre
AU - Shivkumar, Kalyanam
AU - Huang, Henry D.
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2024
Y1 - 2024
N2 - Background: Cardioneuroablation has been emerging as a potential treatment alternative in appropriately selected patients with cardioinhibitory vasovagal syncope (VVS) and functional AV block (AVB). However the majority of available evidence has been derived from retrospective cohort studies performed by experienced operators. Methods: The Cardioneuroablation for the Management of Patients with Recurrent Vasovagal Syncope and Symptomatic Bradyarrhythmias (CNA-FWRD) Registry is a multicenter prospective registry with cross-over design evaluating acute and long-term outcomes of VVS and AVB patients treated by conservative therapy and CNA. Results: The study is a prospective observational registry with cross-over design for analysis of outcomes between a control group (i.e., behavioral and medical therapy only) and intervention group (Cardioneuroablation). Primary and secondary outcomes will only be assessed after enrollment in the registry. The follow-up period will be 3 years after enrollment. Conclusions: There remains a lack of prospective multicentered data for long-term outcomes comparing conservative therapy to radiofrequency CNA procedures particularly for key outcomes including recurrence of syncope, AV block, durable impact of disruption of the autonomic nervous system, and long-term complications after CNA. The CNA-FWRD registry has the potential to help fill this information gap.
AB - Background: Cardioneuroablation has been emerging as a potential treatment alternative in appropriately selected patients with cardioinhibitory vasovagal syncope (VVS) and functional AV block (AVB). However the majority of available evidence has been derived from retrospective cohort studies performed by experienced operators. Methods: The Cardioneuroablation for the Management of Patients with Recurrent Vasovagal Syncope and Symptomatic Bradyarrhythmias (CNA-FWRD) Registry is a multicenter prospective registry with cross-over design evaluating acute and long-term outcomes of VVS and AVB patients treated by conservative therapy and CNA. Results: The study is a prospective observational registry with cross-over design for analysis of outcomes between a control group (i.e., behavioral and medical therapy only) and intervention group (Cardioneuroablation). Primary and secondary outcomes will only be assessed after enrollment in the registry. The follow-up period will be 3 years after enrollment. Conclusions: There remains a lack of prospective multicentered data for long-term outcomes comparing conservative therapy to radiofrequency CNA procedures particularly for key outcomes including recurrence of syncope, AV block, durable impact of disruption of the autonomic nervous system, and long-term complications after CNA. The CNA-FWRD registry has the potential to help fill this information gap.
KW - AV block
KW - Cardioneuroablation
KW - Ganglionated plexi
KW - Syncope
KW - Vasovagal syncope
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U2 - 10.1007/s10840-024-01789-9
DO - 10.1007/s10840-024-01789-9
M3 - Article
AN - SCOPUS:85188080886
SN - 1383-875X
JO - Journal of Interventional Cardiac Electrophysiology
JF - Journal of Interventional Cardiac Electrophysiology
ER -