Cardiac replacement with a total artificial heart as a bridge to transplantation

Jack G. Copeland, Richard G. Smith, Francisco A. Arabia, Paul E. Nolan, Gulshan K. Sethi, Pei H. Tsau, Douglas McClellan, Marvin J. Slepian

Research output: Contribution to journalArticlepeer-review

440 Scopus citations


BACKGROUND The CardioWest Total Artificial Heart orthotopically replaces both native cardiac ventricles and all cardiac valves, thus eliminating problems commonly seen in the bridge to transplantation with left ventricular and biventricular assist devices, such as right heart failure, valvular regurgitation, cardiac arrhythmias, ventricular clots, intraventricular communications, and low blood flows. METHODS We conducted a nonrandomized, prospective study in five centers with the use of historical controls. The purpose was to assess the safety and efficacy of the CardioWest Total Artificial Heart in transplant-eligible patients at risk for imminent death from irreversible biventricular cardiac failure. The primary end points included the rates of survival to heart transplantation and of survival after transplantation. RESULTS Eighty-one patients received the artificial-heart device. The rate of survival to transplantation was 79 percent (95 percent confidence interval, 68 to 87 percent). Of the 35 control patients who met the same entry criteria but did not receive the artificial heart, 46 percent survived to transplantation (P<0.001). Overall, the one-year survival rate among the patients who received the artificial heart was 70 percent, as compared with 31 percent among the controls (P<0.001). One-year and five-year survival rates after transplantation among patients who had received a total artificial heart as a bridge to transplantation were 86 and 64 percent. CONCLUSIONS Implantation of the total artificial heart improved the rate of survival to cardiac transplantation and survival after transplantation. This device prevents death in critically ill patients who have irreversible biventricular failure and are candidates for cardiac transplantation.

Original languageEnglish (US)
Pages (from-to)859-867
Number of pages9
JournalNew England Journal of Medicine
Issue number9
StatePublished - Aug 26 2004

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Cardiac replacement with a total artificial heart as a bridge to transplantation'. Together they form a unique fingerprint.

Cite this