Carcinoembryonic‐like antigen in the urine of patients with carcinoma of the bladder and normal controls

Patrick Guinan, Richard J. Ablin, Nader Sadoughi, Irving M. Bush

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The urine and plasma of 16 patients with carcinoma of the bladder, and 27 normal individudls were studied for the presence of carcinoembryonic antigen (CEA). An attempt was made to determine whether urine CEA‐like antigens are filtered by the kidney or shed directly by the bladder tumor itself. There were elevated levels of CEA in the plasma of patients with bladder tumors. The urine of patients with bladder carcinoma had significantly higher levels of CEA‐like antigen than the urine of normal individuals. These same bladder tumor patients did not have a positive correlation between their plasma CEA and the urine CEA‐like antigen levels. It appears from these findings that urinary carcinoembryonic‐like antigen is shed directly into the urine and not filtered by the kidneys.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalJournal of Surgical Oncology
Volume6
Issue number2
DOIs
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oncology

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