Carboxylesterase-mediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [2H6]ethanol: Preliminary in vitro findings using a rat liver preparation

J. A. Bourland; D. K. Martin; M. Mayersohn

doi:10.1021/js970072x

Carboxylesterase-mediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [²H₆]ethanol: Preliminary in vitro findings using a rat liver preparation

J. A. Bourland, D. K. Martin, M. Mayersohn

Pharmacy Practice and Science

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Original language	English (US)
Pages (from-to)	1494-1496
Number of pages	3
Journal	Journal of pharmaceutical sciences
Volume	86
Issue number	12
DOIs	https://doi.org/10.1021/js970072x
State	Published - 1997

ASJC Scopus subject areas

Pharmaceutical Science

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10.1021/js970072x

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Carboxylesterase-mediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [²H₆]ethanol : Preliminary in vitro findings using a rat liver preparation. / Bourland, J. A.; Martin, D. K.; Mayersohn, M.

In: Journal of pharmaceutical sciences, Vol. 86, No. 12, 1997, p. 1494-1496.

Research output: Contribution to journal › Article › peer-review

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title = "Carboxylesterase-mediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [2H6]ethanol: Preliminary in vitro findings using a rat liver preparation",

author = "Bourland, {J. A.} and Martin, {D. K.} and M. Mayersohn",

note = "Funding Information: The authors gratefully acknowledge support for this work from a grant from the National Institute on Drug Abuse (DA08094) and the synthesis of ethylphenidate by Gene Mash, Ph.D., Department of Chemistry, The University or Arizona (Synthetic Chemistry Core Laboratory, Southwest Environmental Health Sciences Center, supported by NIEHS P-30-ES-06694).",

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AU - Martin, D. K.

AU - Mayersohn, M.

N1 - Funding Information: The authors gratefully acknowledge support for this work from a grant from the National Institute on Drug Abuse (DA08094) and the synthesis of ethylphenidate by Gene Mash, Ph.D., Department of Chemistry, The University or Arizona (Synthetic Chemistry Core Laboratory, Southwest Environmental Health Sciences Center, supported by NIEHS P-30-ES-06694).

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Carboxylesterase-mediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [2H6]ethanol: Preliminary in vitro findings using a rat liver preparation

ASJC Scopus subject areas

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Carboxylesterase-mediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [²H₆]ethanol: Preliminary in vitro findings using a rat liver preparation