Carbon Monoxide and Myocardial Ischemia

Alan W. Katzenstein, Thomas S. Goldbaum, Leo R. Goldbaum, T. E. Dahms, J. Warren, E. R. Bleecker, M. Pagano, E. N. Allred, B. R. Chaitman, J. D. Hackney, S. O. Gottlieb, S. M. Walden, R. H. Selvester

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Abstract

To the Editor: Allred et al. (Nov. 23 issue)1 have concluded that “low levels of carboxyhemoglobin exacerbate myocardial ischemia during graded exercise in subjects with coronary artery disease.” Without appropriate clarification, that conclusion is highly misleading. Carboxyhemoglobin concentrations ranged from 0.62±0.02 to 0.70±0.02 percent in subjects not exposed to carbon monoxide. These values are inexplicably low as compared with those reported elsewhere. The National Research Council2 noted that “in nonsmokers without occupational exposure to carbon monoxide, carboxyhemoglobin ranges from 0.5% to 1.5%” and attributed most of this to endogenous carbon monoxide, citing one study of nonsmokers in which carboxyhemoglobin levels…

Original languageEnglish (US)
Pages (from-to)1086-1087
Number of pages2
JournalNew England Journal of Medicine
Volume322
Issue number15
DOIs
StatePublished - Apr 12 1990
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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