Carbon Monoxide and Myocardial Ischemia

Alan W. Katzenstein; Thomas S. Goldbaum; Leo R. Goldbaum; T. E. Dahms; J. Warren; E. R. Bleecker; M. Pagano; E. N. Allred; B. R. Chaitman; J. D. Hackney; S. O. Gottlieb; S. M. Walden; R. H. Selvester

doi:10.1056/NEJM199004123221516

Carbon Monoxide and Myocardial Ischemia

Alan W. Katzenstein, Thomas S. Goldbaum, Leo R. Goldbaum, T. E. Dahms, J. Warren, E. R. Bleecker, M. Pagano, E. N. Allred, B. R. Chaitman, J. D. Hackney, S. O. Gottlieb, S. M. Walden, R. H. Selvester

Research output: Contribution to journal › Letter › peer-review

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Abstract

To the Editor: Allred et al. (Nov. 23 issue)¹ have concluded that “low levels of carboxyhemoglobin exacerbate myocardial ischemia during graded exercise in subjects with coronary artery disease.” Without appropriate clarification, that conclusion is highly misleading. Carboxyhemoglobin concentrations ranged from 0.62±0.02 to 0.70±0.02 percent in subjects not exposed to carbon monoxide. These values are inexplicably low as compared with those reported elsewhere. The National Research Council² noted that “in nonsmokers without occupational exposure to carbon monoxide, carboxyhemoglobin ranges from 0.5% to 1.5%” and attributed most of this to endogenous carbon monoxide, citing one study of nonsmokers in which carboxyhemoglobin levels…

Original language	English (US)
Pages (from-to)	1086-1087
Number of pages	2
Journal	New England Journal of Medicine
Volume	322
Issue number	15
DOIs	https://doi.org/10.1056/NEJM199004123221516
State	Published - Apr 12 1990
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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title = "Carbon Monoxide and Myocardial Ischemia",

abstract = "To the Editor: Allred et al. (Nov. 23 issue)1 have concluded that “low levels of carboxyhemoglobin exacerbate myocardial ischemia during graded exercise in subjects with coronary artery disease.” Without appropriate clarification, that conclusion is highly misleading. Carboxyhemoglobin concentrations ranged from 0.62±0.02 to 0.70±0.02 percent in subjects not exposed to carbon monoxide. These values are inexplicably low as compared with those reported elsewhere. The National Research Council2 noted that “in nonsmokers without occupational exposure to carbon monoxide, carboxyhemoglobin ranges from 0.5% to 1.5%” and attributed most of this to endogenous carbon monoxide, citing one study of nonsmokers in which carboxyhemoglobin levels…",

author = "Katzenstein, {Alan W.} and Goldbaum, {Thomas S.} and Goldbaum, {Leo R.} and Dahms, {T. E.} and J. Warren and Bleecker, {E. R.} and M. Pagano and Allred, {E. N.} and Chaitman, {B. R.} and Hackney, {J. D.} and Gottlieb, {S. O.} and Walden, {S. M.} and Selvester, {R. H.}",

year = "1990",

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day = "12",

doi = "10.1056/NEJM199004123221516",

language = "English (US)",

volume = "322",

pages = "1086--1087",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "15",

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TY - JOUR

T1 - Carbon Monoxide and Myocardial Ischemia

AU - Katzenstein, Alan W.

AU - Goldbaum, Thomas S.

AU - Goldbaum, Leo R.

AU - Dahms, T. E.

AU - Warren, J.

AU - Bleecker, E. R.

AU - Pagano, M.

AU - Allred, E. N.

AU - Chaitman, B. R.

AU - Hackney, J. D.

AU - Gottlieb, S. O.

AU - Walden, S. M.

AU - Selvester, R. H.

PY - 1990/4/12

Y1 - 1990/4/12

N2 - To the Editor: Allred et al. (Nov. 23 issue)1 have concluded that “low levels of carboxyhemoglobin exacerbate myocardial ischemia during graded exercise in subjects with coronary artery disease.” Without appropriate clarification, that conclusion is highly misleading. Carboxyhemoglobin concentrations ranged from 0.62±0.02 to 0.70±0.02 percent in subjects not exposed to carbon monoxide. These values are inexplicably low as compared with those reported elsewhere. The National Research Council2 noted that “in nonsmokers without occupational exposure to carbon monoxide, carboxyhemoglobin ranges from 0.5% to 1.5%” and attributed most of this to endogenous carbon monoxide, citing one study of nonsmokers in which carboxyhemoglobin levels…

AB - To the Editor: Allred et al. (Nov. 23 issue)1 have concluded that “low levels of carboxyhemoglobin exacerbate myocardial ischemia during graded exercise in subjects with coronary artery disease.” Without appropriate clarification, that conclusion is highly misleading. Carboxyhemoglobin concentrations ranged from 0.62±0.02 to 0.70±0.02 percent in subjects not exposed to carbon monoxide. These values are inexplicably low as compared with those reported elsewhere. The National Research Council2 noted that “in nonsmokers without occupational exposure to carbon monoxide, carboxyhemoglobin ranges from 0.5% to 1.5%” and attributed most of this to endogenous carbon monoxide, citing one study of nonsmokers in which carboxyhemoglobin levels…

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U2 - 10.1056/NEJM199004123221516

DO - 10.1056/NEJM199004123221516

M3 - Letter

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SN - 0028-4793

VL - 322

SP - 1086

EP - 1087

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 15

ER -

Carbon Monoxide and Myocardial Ischemia

Abstract

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