Canonical and Non-Canonical Wnt Signaling in Immune Cells

Wook Jin Chae, Alfred L.M. Bothwell

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations

Abstract

Cell differentiation, proliferation, and death are vital for immune homeostasis. Wnt signaling plays essential roles in processes across species. The roles of Wnt signaling proteins and Wnt ligands have been studied in the past, but the context-dependent mechanisms and functions of these pathways in immune responses remain unclear. Recent findings regarding the role of Wnt ligands and Wnt signaling in immune cells and their immunomodulatory mechanisms suggest that Wnt ligands and signaling are significant in regulating immune responses. We introduce recent key findings and future perspectives on Wnt ligands and their signaling pathways in immune cells as well as the immunological roles and functions of Wnt antagonists.

Original languageEnglish (US)
Pages (from-to)830-847
Number of pages18
JournalTrends in Immunology
Volume39
Issue number10
DOIs
StatePublished - Oct 2018
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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