TY - JOUR
T1 - Canonical and Non-Canonical Wnt Signaling in Immune Cells
AU - Chae, Wook Jin
AU - Bothwell, Alfred L.M.
N1 - Funding Information:
This work is supported by National Institutes of Health grants R01CA168670 , R21AI23858 , R56AI27794 , and R21AI107957 , and National Cancer Institute grant P30CA016359 .
Publisher Copyright:
© 2018
PY - 2018/10
Y1 - 2018/10
N2 - Cell differentiation, proliferation, and death are vital for immune homeostasis. Wnt signaling plays essential roles in processes across species. The roles of Wnt signaling proteins and Wnt ligands have been studied in the past, but the context-dependent mechanisms and functions of these pathways in immune responses remain unclear. Recent findings regarding the role of Wnt ligands and Wnt signaling in immune cells and their immunomodulatory mechanisms suggest that Wnt ligands and signaling are significant in regulating immune responses. We introduce recent key findings and future perspectives on Wnt ligands and their signaling pathways in immune cells as well as the immunological roles and functions of Wnt antagonists.
AB - Cell differentiation, proliferation, and death are vital for immune homeostasis. Wnt signaling plays essential roles in processes across species. The roles of Wnt signaling proteins and Wnt ligands have been studied in the past, but the context-dependent mechanisms and functions of these pathways in immune responses remain unclear. Recent findings regarding the role of Wnt ligands and Wnt signaling in immune cells and their immunomodulatory mechanisms suggest that Wnt ligands and signaling are significant in regulating immune responses. We introduce recent key findings and future perspectives on Wnt ligands and their signaling pathways in immune cells as well as the immunological roles and functions of Wnt antagonists.
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U2 - 10.1016/j.it.2018.08.006
DO - 10.1016/j.it.2018.08.006
M3 - Review article
C2 - 30213499
AN - SCOPUS:85053003866
SN - 1471-4906
VL - 39
SP - 830
EP - 847
JO - Trends in Immunology
JF - Trends in Immunology
IS - 10
ER -