Cancer prevention by retinoids: Role of immunological modification

Ronald Ross Watson; Satoru Moriguchi

doi:10.1016/S0271-5317(85)80247-5

Cancer prevention by retinoids: Role of immunological modification

Ronald Ross Watson
, Satoru Moriguchi

Health Promotion Sciences

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

High retinoid intakes have be associated with decreased risk of cancer. In addition retinoids are immunomodulating compounds. A mechanism to help explain their anticancer action may be immunosuppression during vitamin A deficiency or immunoenhancement extremely high intakes. Some conditions such as Schistosomiasis are associated with increased cancer risk, immunosuppressions, and low vitamin A levels in serum. In vitro, retinol suppressed T-lymphocyte functions. However, high dietary vitamin A enhanced macrophage functions, which may help explain greater cancer resistance.

Original language	English (US)
Pages (from-to)	663-675
Number of pages	13
Journal	Nutrition Research
Volume	5
Issue number	6
DOIs	https://doi.org/10.1016/S0271-5317(85)80247-5
State	Published - Jun 1985

Keywords

Schistosomiasis
cancer
immunity
retinol
vitamin A

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Nutrition and Dietetics

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10.1016/S0271-5317(85)80247-5

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@article{02c502bbebb64211b1750fe023f02421,

title = "Cancer prevention by retinoids: Role of immunological modification",

abstract = "High retinoid intakes have be associated with decreased risk of cancer. In addition retinoids are immunomodulating compounds. A mechanism to help explain their anticancer action may be immunosuppression during vitamin A deficiency or immunoenhancement extremely high intakes. Some conditions such as Schistosomiasis are associated with increased cancer risk, immunosuppressions, and low vitamin A levels in serum. In vitro, retinol suppressed T-lymphocyte functions. However, high dietary vitamin A enhanced macrophage functions, which may help explain greater cancer resistance.",

keywords = "Schistosomiasis, cancer, immunity, retinol, vitamin A",

author = "Watson, \{Ronald Ross\} and Satoru Moriguchi",

note = "Funding Information: Research supported in part by grants from National Cancer Institute CA-27502, Wallace Genetics, Inc. and Phi Beta Psl Sorority.",

year = "1985",

month = jun,

doi = "10.1016/S0271-5317(85)80247-5",

language = "English (US)",

volume = "5",

pages = "663--675",

journal = "Nutrition Research",

issn = "0271-5317",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Cancer prevention by retinoids

T2 - Role of immunological modification

AU - Watson, Ronald Ross

AU - Moriguchi, Satoru

N1 - Funding Information: Research supported in part by grants from National Cancer Institute CA-27502, Wallace Genetics, Inc. and Phi Beta Psl Sorority.

PY - 1985/6

Y1 - 1985/6

N2 - High retinoid intakes have be associated with decreased risk of cancer. In addition retinoids are immunomodulating compounds. A mechanism to help explain their anticancer action may be immunosuppression during vitamin A deficiency or immunoenhancement extremely high intakes. Some conditions such as Schistosomiasis are associated with increased cancer risk, immunosuppressions, and low vitamin A levels in serum. In vitro, retinol suppressed T-lymphocyte functions. However, high dietary vitamin A enhanced macrophage functions, which may help explain greater cancer resistance.

AB - High retinoid intakes have be associated with decreased risk of cancer. In addition retinoids are immunomodulating compounds. A mechanism to help explain their anticancer action may be immunosuppression during vitamin A deficiency or immunoenhancement extremely high intakes. Some conditions such as Schistosomiasis are associated with increased cancer risk, immunosuppressions, and low vitamin A levels in serum. In vitro, retinol suppressed T-lymphocyte functions. However, high dietary vitamin A enhanced macrophage functions, which may help explain greater cancer resistance.

KW - Schistosomiasis

KW - cancer

KW - immunity

KW - retinol

KW - vitamin A

UR - https://www.scopus.com/pages/publications/0021803778

UR - https://www.scopus.com/pages/publications/0021803778#tab=citedBy

U2 - 10.1016/S0271-5317(85)80247-5

DO - 10.1016/S0271-5317(85)80247-5

M3 - Review article

AN - SCOPUS:0021803778

SN - 0271-5317

VL - 5

SP - 663

EP - 675

JO - Nutrition Research

JF - Nutrition Research

IS - 6

ER -

Cancer prevention by retinoids: Role of immunological modification

Abstract

Keywords

ASJC Scopus subject areas

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