Cancer of the Oropharynx

David A. Clump; Julie E. Bauman; Robert L. Ferris

doi:10.1016/j.soc.2015.03.014

Cancer of the Oropharynx

David A. Clump, Julie E. Bauman, Robert L. Ferris

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

The oropharynx has a crucial role in swallowing because of the surrounding constrictor musculature, need for mobility and pliability, and proximity of the base of tongue to the larynx. Human papilloma virus (HPV) infection as a cause of oropharyngeal squamous cell carcinoma has increased dramatically in proportion and overall numbers of oropharyngeal squamous cell carcinoma cases. Better clinical response to therapy and younger age of the HPV+ oropharyngeal squamous cell carcinoma patients have caused functional and quality-of-life considerations to become more important endpoints in evaluating efficacy of therapeutic options; "deintensification" to ameliorate toxicity is under investigation for this population.

Original language	English (US)
Pages (from-to)	509-520
Number of pages	12
Journal	Surgical Oncology Clinics of North America
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.soc.2015.03.014
State	Published - Jul 1 2015
Externally published	Yes

Keywords

Chemoradiation
Head and neck squamous cell carcinoma
Human papillomavirus
Oropharynx
Pathogenesis
Transoral surgery

ASJC Scopus subject areas

Surgery
Oncology

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10.1016/j.soc.2015.03.014

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title = "Cancer of the Oropharynx",

abstract = "The oropharynx has a crucial role in swallowing because of the surrounding constrictor musculature, need for mobility and pliability, and proximity of the base of tongue to the larynx. Human papilloma virus (HPV) infection as a cause of oropharyngeal squamous cell carcinoma has increased dramatically in proportion and overall numbers of oropharyngeal squamous cell carcinoma cases. Better clinical response to therapy and younger age of the HPV+ oropharyngeal squamous cell carcinoma patients have caused functional and quality-of-life considerations to become more important endpoints in evaluating efficacy of therapeutic options; {"}deintensification{"} to ameliorate toxicity is under investigation for this population.",

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AU - Bauman, Julie E.

AU - Ferris, Robert L.

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AB - The oropharynx has a crucial role in swallowing because of the surrounding constrictor musculature, need for mobility and pliability, and proximity of the base of tongue to the larynx. Human papilloma virus (HPV) infection as a cause of oropharyngeal squamous cell carcinoma has increased dramatically in proportion and overall numbers of oropharyngeal squamous cell carcinoma cases. Better clinical response to therapy and younger age of the HPV+ oropharyngeal squamous cell carcinoma patients have caused functional and quality-of-life considerations to become more important endpoints in evaluating efficacy of therapeutic options; "deintensification" to ameliorate toxicity is under investigation for this population.

KW - Chemoradiation

KW - Head and neck squamous cell carcinoma

KW - Human papillomavirus

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KW - Pathogenesis

KW - Transoral surgery

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Cancer of the Oropharynx

Abstract

Keywords

ASJC Scopus subject areas

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