Cancer of the Oropharynx

David A. Clump, Julie E. Bauman, Robert L. Ferris

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

The oropharynx has a crucial role in swallowing because of the surrounding constrictor musculature, need for mobility and pliability, and proximity of the base of tongue to the larynx. Human papilloma virus (HPV) infection as a cause of oropharyngeal squamous cell carcinoma has increased dramatically in proportion and overall numbers of oropharyngeal squamous cell carcinoma cases. Better clinical response to therapy and younger age of the HPV+ oropharyngeal squamous cell carcinoma patients have caused functional and quality-of-life considerations to become more important endpoints in evaluating efficacy of therapeutic options; "deintensification" to ameliorate toxicity is under investigation for this population.

Original languageEnglish (US)
Pages (from-to)509-520
Number of pages12
JournalSurgical Oncology Clinics of North America
Volume24
Issue number3
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Keywords

  • Chemoradiation
  • Head and neck squamous cell carcinoma
  • Human papillomavirus
  • Oropharynx
  • Pathogenesis
  • Transoral surgery

ASJC Scopus subject areas

  • Surgery
  • Oncology

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