Cancer immunoediting: A game theoretical approach

Fatemeh Tavakoli, Javad Salimi Sartakhti, Mohammad Hossein Manshaei, David Basanta

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The role of the immune system in tumor development increasingly includes the idea of cancer immunoediting. It comprises three phases: elimination, equilibrium, and escape. In the first phase, elimination, transformed cells are recognized and destroyed by immune system. The rare tumor cells that are not destroyed in this phase may then enter the equilibrium phase, where their growth is prevented by immunity mechanisms. The escape phase represents the final phase of this process, where cancer cells begin to grow unconstrained by the immune system. In this study, we describe and analyze an evolutionary game theoretical model of proliferating, quiescent, and immune cells interactions for the first time. The proposed model is evaluated with constant and dynamic approaches. Population dynamics and interactions between the immune system and cancer cells are investigated. Stability of equilibria or critical points are analyzed by applying algebraic analysis. This model allows us to understand the process of cancer development and might help us design better treatment strategies to account for immunoediting.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalIn Silico Biology
Volume14
Issue number1-2
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • cancer
  • Evolutionary game theory
  • immunoediting
  • replicator dynamics

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Computational Mathematics
  • Computational Theory and Mathematics

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