Cancer and inflammatory bowel disease in the elderly

Sasha Taleban, Emad Elquza, Corinne Gower-Rousseau, Laurent Peyrin-Biroulet

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Cancer may be a complication of inflammatory bowel disease (IBD) or its treatments. In older Crohn's disease and ulcerative colitis patients, the risk of malignancy is of particular concern. IBD diagnosis at an advanced age is associated with earlier development of colitis-associated colorectal cancer. Thiopurine use in older IBD patients is tied to an increased risk of non-Hodgkin's lymphoma, nonmelanoma skin cancer, and urinary tract cancers. Additionally, older age is accompanied by multimorbidity, an increased risk of malnutrition, and decreased life expectancy, factors that complicate the management of cancer in the elderly. The optimal approach to the increased risk of malignancy in older age IBD is appropriate cancer screening and medical treatment. This may include age-specific colorectal cancer screening and limiting UV radiation exposure. With a growing number of older IBD patients, further studies are necessary to delineate the risk of cancer in this population.

Original languageEnglish (US)
Pages (from-to)1105-1111
Number of pages7
JournalDigestive and Liver Disease
Issue number10
StatePublished - Oct 1 2016


  • Crohn's disease
  • Malignancy
  • Older
  • Ulcerative colitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Cancer and inflammatory bowel disease in the elderly'. Together they form a unique fingerprint.

Cite this