Can equal pA2 values be compatible with receptor differences?

Robert B. Raffa, Jeffry L. Vaught, Frank Porreca

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Situations exist in which pA2 analysis leads to conclusions about receptor differentiation that conflict with those drawn from other convincing lines of evidence. Robert Raffa and colleagues address this issue in its broadest context, particularly in relationship to the concept of accessory binding sites, using the controversy of δ-opioid receptor-mediated antinociception as an example. When the possibility of accessory binding sites is considered, it becomes dear that the finding of equal pA2 values does not necessarily mean action at the same receptor, and that the finding of unequal pA2 values does not necessarily confirm action at different receptors.

Original languageEnglish (US)
Pages (from-to)183-185
Number of pages3
JournalTrends in Pharmacological Sciences
Issue number5
StatePublished - May 1989

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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