TY - JOUR
T1 - Calpain-10 gene polymorphisms and type 2 diabetes in West Africans
T2 - The Africa America Diabetes Mellitus (AADM) Study
AU - Chen, Yuanxiu
AU - Kittles, Rick
AU - Zhou, Jie
AU - Chen, Guanjie
AU - Adeyemo, Adebowale
AU - Panguluri, Ramesh K.
AU - Chen, Weidong
AU - Amoah, Albert
AU - Opoku, Victoria
AU - Acheampong, Joseph
AU - Agyenim-Boateng, Kofi
AU - Eghan, Benjamin Ackon
AU - Nyantaki, Awuah
AU - Oli, Johnnie
AU - Okafor, Godfrey
AU - Ofoegbu, Esther
AU - Osotimehin, Babatunde
AU - Abbiyesuku, Fayeofori
AU - Johnson, Thomas
AU - Fasanmade, Olufemi
AU - Rufus, Theresa
AU - Furbert-Harris, Paulette
AU - Daniel, Harold I.
AU - Berg, Kate A.
AU - Collins, Francis S.
AU - Dunston, Georgia M.
AU - Rotimi, Charles N.
PY - 2005/2
Y1 - 2005/2
N2 - To investigate whether the three single nucleotide polymorphisms (SNPs), SNP-43, -56, and -63 of CAPN10 were associated with type 2 diabetes in a West African cohort. A total of 347 diabetic subjects and 148 unaffected controls from four ethnic groups in two West African countries were enrolled in this study. After genotyping three SNPs of CAPN10 and one SNP from CYP19, the allele, genotype, and haplotype frequencies as well as the odds ratios were calculated to test their association with type 2 diabetes. None of the alleles or genotypes was associated with type 2 diabetes. Although statistical analysis indicated that haplotype 221 was associated with type 2 diabetes (OR, 3.765; 95% CI, 1.577-8.989) in the two ethnic groups of Nigeria, the same haplotype did not show any association with type 2 diabetes in the two ethnic groups in Ghana (OR, 0.906; 95% CI, 0.322-2.552). Considering the relatively low frequency of haplotype 221 and that none of the haplotypes including 221 was associated with any of the diabetes-related quantitative traits tested, it is concluded that SNP-43, -56, and -63 of the CAPN10 gene variants may play a limited role in the risk of type 2 diabetes risks in this cohort of West Africans.
AB - To investigate whether the three single nucleotide polymorphisms (SNPs), SNP-43, -56, and -63 of CAPN10 were associated with type 2 diabetes in a West African cohort. A total of 347 diabetic subjects and 148 unaffected controls from four ethnic groups in two West African countries were enrolled in this study. After genotyping three SNPs of CAPN10 and one SNP from CYP19, the allele, genotype, and haplotype frequencies as well as the odds ratios were calculated to test their association with type 2 diabetes. None of the alleles or genotypes was associated with type 2 diabetes. Although statistical analysis indicated that haplotype 221 was associated with type 2 diabetes (OR, 3.765; 95% CI, 1.577-8.989) in the two ethnic groups of Nigeria, the same haplotype did not show any association with type 2 diabetes in the two ethnic groups in Ghana (OR, 0.906; 95% CI, 0.322-2.552). Considering the relatively low frequency of haplotype 221 and that none of the haplotypes including 221 was associated with any of the diabetes-related quantitative traits tested, it is concluded that SNP-43, -56, and -63 of the CAPN10 gene variants may play a limited role in the risk of type 2 diabetes risks in this cohort of West Africans.
KW - Calpain-10
KW - Insulin
KW - SNP-43
KW - Type 2 Diabetes
KW - West Africa
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UR - http://www.scopus.com/inward/citedby.url?scp=19944430210&partnerID=8YFLogxK
U2 - 10.1016/j.annepidem.2004.05.014
DO - 10.1016/j.annepidem.2004.05.014
M3 - Article
C2 - 15652721
AN - SCOPUS:19944430210
SN - 1047-2797
VL - 15
SP - 153
EP - 159
JO - Annals of epidemiology
JF - Annals of epidemiology
IS - 2
ER -