Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography

Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Linxi Shi, Srinivasan Vedantham, Steven P. Poplack, Andrew Karellas, Brian W. Pogue, Keith D. Paulsen

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Calibration of a three-dimensional multimodal digital breast tomosynthesis (DBT) x-ray and non-fiber based near infrared spectral tomography (NIRST) system is challenging but essential for clinical studies. Phantom imaging results yielded linear contrast recovery of total hemoglobin (HbT) concentration for cylindrical inclusions of 15 mm, 10 mm and 7 mm with a 3.5% decrease in the HbT estimate for each 1 cm increase in inclusion depth. A clinical exam of a patient’s breast containing both benign and malignant lesions was successfully imaged, with greater HbT was found in the malignancy relative to the benign abnormality and fibroglandular regions (11 μM vs. 9.5 μM). Tools developed improved imaging system characterization and optimization of signal quality, which will ultimately improve patient selection and subsequent clinical trial results.

Original languageEnglish (US)
Article number250601
Pages (from-to)4981-4991
Number of pages11
JournalBiomedical Optics Express
Issue number12
StatePublished - Nov 19 2015


  • Imaging systems
  • Mammography
  • Medical optics instrumentation

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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