Calcium metabolism and dietary calcium in salt sensitive hypertension

James R. Sowers, Michael B. Zemel, Paula G. Zemel, Paul R. Standley

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Evidence has accumulated over the past decade that suggests a relationship between low calcium intake, abnormalities in cation metabolism and hyperten­sion in certain segments of the essential hyperten­sion population. This evidence has been developed from epidemiological data, calcium intervention trials and observations related to biochemical alter­ations suggestive of a calcium deficiency in certain patients with hypertension and in animal models of essential hypertension. It is becoming increasingly evident that salt sensitive individuals are especiallylikely to be characterized by abnormalities of cal­cium metabolism and blood pressure responses to dietary calcium. In this review the role of calcium in the regulation of blood pressure is examined with an emphasis on epidemiological, biochemical, he­modynamic and dietary intervention data in the salt sensitive hypertensive patient. Am J Hypertens 1991;4:557-563.

Original languageEnglish (US)
Pages (from-to)557-563
Number of pages7
JournalAmerican Journal of Hypertension
Issue number6
StatePublished - Mar 1991


  • Calcium
  • Hypertension
  • Salt sensitivity

ASJC Scopus subject areas

  • Internal Medicine


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