c-Ha-ras-1 oncogene lies between β-globin and insulin loci on human chromosome 11p

E. R. Fearon; S. E. Antonarakis; D. A. Meyers; M. A. Levine

c-Ha-ras-1 oncogene lies between β-globin and insulin loci on human chromosome 11p

E. R. Fearon, S. E. Antonarakis, D. A. Meyers, M. A. Levine

Research output: Contribution to journal › Article › peer-review

Abstract

DNA sequence polymorphisms have been used to determine the linear order and recombinational distances separating the Harvey rat 1 oncogene (c-Ha-ras-1), β-globin, insulin, and parathyroid hormone genes on the short arm of human chromosome 11. Our results indicate that c-Ha-ras-1 is closely linked to both the β-globin locus (Θ = .08 [8 centimorgans], lod score = 5.11) and the insulin locus (Θ = .04 [4 centimorgans], lod score = 3.31). Furthermore, the probable order of these loci on chromosome 11p is centromere-parathyroid hormone-β globin-c-Ha-ras-1-insulin.

Original language	English (US)
Pages (from-to)	329-337
Number of pages	9
Journal	American Journal of Human Genetics
Volume	36
Issue number	2
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Cite this

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title = "c-Ha-ras-1 oncogene lies between β-globin and insulin loci on human chromosome 11p",

abstract = "DNA sequence polymorphisms have been used to determine the linear order and recombinational distances separating the Harvey rat 1 oncogene (c-Ha-ras-1), β-globin, insulin, and parathyroid hormone genes on the short arm of human chromosome 11. Our results indicate that c-Ha-ras-1 is closely linked to both the β-globin locus (Θ = .08 [8 centimorgans], lod score = 5.11) and the insulin locus (Θ = .04 [4 centimorgans], lod score = 3.31). Furthermore, the probable order of these loci on chromosome 11p is centromere-parathyroid hormone-β globin-c-Ha-ras-1-insulin.",

author = "Fearon, {E. R.} and Antonarakis, {S. E.} and Meyers, {D. A.} and Levine, {M. A.}",

year = "1984",

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T1 - c-Ha-ras-1 oncogene lies between β-globin and insulin loci on human chromosome 11p

AU - Fearon, E. R.

AU - Antonarakis, S. E.

AU - Meyers, D. A.

AU - Levine, M. A.

PY - 1984

Y1 - 1984

N2 - DNA sequence polymorphisms have been used to determine the linear order and recombinational distances separating the Harvey rat 1 oncogene (c-Ha-ras-1), β-globin, insulin, and parathyroid hormone genes on the short arm of human chromosome 11. Our results indicate that c-Ha-ras-1 is closely linked to both the β-globin locus (Θ = .08 [8 centimorgans], lod score = 5.11) and the insulin locus (Θ = .04 [4 centimorgans], lod score = 3.31). Furthermore, the probable order of these loci on chromosome 11p is centromere-parathyroid hormone-β globin-c-Ha-ras-1-insulin.

AB - DNA sequence polymorphisms have been used to determine the linear order and recombinational distances separating the Harvey rat 1 oncogene (c-Ha-ras-1), β-globin, insulin, and parathyroid hormone genes on the short arm of human chromosome 11. Our results indicate that c-Ha-ras-1 is closely linked to both the β-globin locus (Θ = .08 [8 centimorgans], lod score = 5.11) and the insulin locus (Θ = .04 [4 centimorgans], lod score = 3.31). Furthermore, the probable order of these loci on chromosome 11p is centromere-parathyroid hormone-β globin-c-Ha-ras-1-insulin.

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c-Ha-ras-1 oncogene lies between β-globin and insulin loci on human chromosome 11p

Abstract

ASJC Scopus subject areas

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