Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned

Ryan Choi; Matthew A. Hulverson; Wenlin Huang; Rama S.R. Vidadala; Grant R. Whitman; Lynn K. Barrett; Deborah A. Schaefer; Dana P. Betzer; Michael W. Riggs; J. Stone Doggett; Andrew Hemphill; Luis Miguel Ortega-Mora; Molly C. McCloskey; Samuel L.M. Arnold; Robert C. Hackman; Kennan C. Marsh; James J. Lynch; Gail M. Freiberg; Bruce E. Leroy; Dale J. Kempf; Robert K.M. Choy; Eugenio L. de Hostos; Dustin J. Maly; Erkang Fan; Kayode K. Ojo; Wesley C. Van Voorhis

doi:10.1016/j.ijpara.2020.01.006

Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned

Ryan Choi
, Matthew A. Hulverson
, Wenlin Huang
, Rama S.R. Vidadala
, Grant R. Whitman
, Lynn K. Barrett
, Deborah A. Schaefer
, Dana P. Betzer
, Michael W. Riggs
, J. Stone Doggett
, Andrew Hemphill
, Luis Miguel Ortega-Mora
, Molly C. McCloskey
, Samuel L.M. Arnold
, Robert C. Hackman
, Kennan C. Marsh
, James J. Lynch
, Gail M. Freiberg
, Bruce E. Leroy
, Dale J. Kempf

Robert K.M. Choy, Eugenio L. de Hostos, Dustin J. Maly, Erkang Fan, Kayode K. Ojo, Wesley C. Van Voorhis

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.

Original language	English (US)
Pages (from-to)	413-422
Number of pages	10
Journal	International Journal for Parasitology
Volume	50
Issue number	5
DOIs	https://doi.org/10.1016/j.ijpara.2020.01.006
State	Published - May 2020
Externally published	Yes

Keywords

Apicomplexa
Bumped Kinase Inhibitor
Calcium-dependent Protein Kinases
Cryptosporidium
Gatekeeper
Neospora
Sarcocystis
Toxoplasma

ASJC Scopus subject areas

Parasitology
Infectious Diseases

Access to Document

10.1016/j.ijpara.2020.01.006

Cite this

Choi, R., Hulverson, M. A., Huang, W., Vidadala, R. S. R., Whitman, G. R., Barrett, L. K., Schaefer, D. A., Betzer, D. P., Riggs, M. W., Doggett, J. S., Hemphill, A., Ortega-Mora, L. M., McCloskey, M. C., Arnold, S. L. M., Hackman, R. C., Marsh, K. C., Lynch, J. J., Freiberg, G. M., Leroy, B. E., ... Van Voorhis, W. C. (2020). Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned. International Journal for Parasitology, 50(5), 413-422. https://doi.org/10.1016/j.ijpara.2020.01.006

Choi, R, Hulverson, MA, Huang, W, Vidadala, RSR, Whitman, GR, Barrett, LK, Schaefer, DA, Betzer, DP, Riggs, MW, Doggett, JS, Hemphill, A, Ortega-Mora, LM, McCloskey, MC, Arnold, SLM, Hackman, RC, Marsh, KC, Lynch, JJ, Freiberg, GM, Leroy, BE, Kempf, DJ, Choy, RKM, de Hostos, EL, Maly, DJ, Fan, E, Ojo, KK & Van Voorhis, WC 2020, 'Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned', International Journal for Parasitology, vol. 50, no. 5, pp. 413-422. https://doi.org/10.1016/j.ijpara.2020.01.006

@article{134c6eee417d46859c15b0a9d7627523,

title = "Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned",

abstract = "Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.",

keywords = "Apicomplexa, Bumped Kinase Inhibitor, Calcium-dependent Protein Kinases, Cryptosporidium, Gatekeeper, Neospora, Sarcocystis, Toxoplasma",

author = "Ryan Choi and Hulverson, \{Matthew A.\} and Wenlin Huang and Vidadala, \{Rama S.R.\} and Whitman, \{Grant R.\} and Barrett, \{Lynn K.\} and Schaefer, \{Deborah A.\} and Betzer, \{Dana P.\} and Riggs, \{Michael W.\} and Doggett, \{J. Stone\} and Andrew Hemphill and Ortega-Mora, \{Luis Miguel\} and McCloskey, \{Molly C.\} and Arnold, \{Samuel L.M.\} and Hackman, \{Robert C.\} and Marsh, \{Kennan C.\} and Lynch, \{James J.\} and Freiberg, \{Gail M.\} and Leroy, \{Bruce E.\} and Kempf, \{Dale J.\} and Choy, \{Robert K.M.\} and \{de Hostos\}, \{Eugenio L.\} and Maly, \{Dustin J.\} and Erkang Fan and Ojo, \{Kayode K.\} and \{Van Voorhis\}, \{Wesley C.\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = may,

doi = "10.1016/j.ijpara.2020.01.006",

language = "English (US)",

volume = "50",

pages = "413--422",

journal = "International Journal for Parasitology",

issn = "0020-7519",

publisher = "Elsevier Ltd",

number = "5",

}

TY - JOUR

T1 - Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases

T2 - lessons learned

AU - Choi, Ryan

AU - Hulverson, Matthew A.

AU - Huang, Wenlin

AU - Vidadala, Rama S.R.

AU - Whitman, Grant R.

AU - Barrett, Lynn K.

AU - Schaefer, Deborah A.

AU - Betzer, Dana P.

AU - Riggs, Michael W.

AU - Doggett, J. Stone

AU - Hemphill, Andrew

AU - Ortega-Mora, Luis Miguel

AU - McCloskey, Molly C.

AU - Arnold, Samuel L.M.

AU - Hackman, Robert C.

AU - Marsh, Kennan C.

AU - Lynch, James J.

AU - Freiberg, Gail M.

AU - Leroy, Bruce E.

AU - Kempf, Dale J.

AU - Choy, Robert K.M.

AU - de Hostos, Eugenio L.

AU - Maly, Dustin J.

AU - Fan, Erkang

AU - Ojo, Kayode K.

AU - Van Voorhis, Wesley C.

PY - 2020/5

Y1 - 2020/5

N2 - Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.

AB - Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.

KW - Apicomplexa

KW - Bumped Kinase Inhibitor

KW - Calcium-dependent Protein Kinases

KW - Cryptosporidium

KW - Gatekeeper

KW - Neospora

KW - Sarcocystis

KW - Toxoplasma

UR - https://www.scopus.com/pages/publications/85083314738

UR - https://www.scopus.com/pages/publications/85083314738#tab=citedBy

U2 - 10.1016/j.ijpara.2020.01.006

DO - 10.1016/j.ijpara.2020.01.006

M3 - Review article

C2 - 32224121

AN - SCOPUS:85083314738

SN - 0020-7519

VL - 50

SP - 413

EP - 422

JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 5

ER -

Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this