Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned

Ryan Choi; Matthew A. Hulverson; Wenlin Huang; Rama S.R. Vidadala; Grant R. Whitman; Lynn K. Barrett; Deborah A. Schaefer; Dana P. Betzer; Michael W. Riggs; J. Stone Doggett; Andrew Hemphill; Luis Miguel Ortega-Mora; Molly C. McCloskey; Samuel L.M. Arnold; Robert C. Hackman; Kennan C. Marsh; James J. Lynch; Gail M. Freiberg; Bruce E. Leroy; Dale J. Kempf; Robert K.M. Choy; Eugenio L. de Hostos; Dustin J. Maly; Erkang Fan; Kayode K. Ojo; Wesley C. Van Voorhis

doi:10.1016/j.ijpara.2020.01.006

Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned

Ryan Choi, Matthew A. Hulverson, Wenlin Huang, Rama S.R. Vidadala, Grant R. Whitman, Lynn K. Barrett, Deborah A. Schaefer, Dana P. Betzer, Michael W. Riggs, J. Stone Doggett, Andrew Hemphill, Luis Miguel Ortega-Mora, Molly C. McCloskey, Samuel L.M. Arnold, Robert C. Hackman, Kennan C. Marsh, James J. Lynch, Gail M. Freiberg, Bruce E. Leroy, Dale J. KempfRobert K.M. Choy, Eugenio L. de Hostos, Dustin J. Maly, Erkang Fan, Kayode K. Ojo, Wesley C. Van Voorhis

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.

Original language	English (US)
Pages (from-to)	413-422
Number of pages	10
Journal	International Journal for Parasitology
Volume	50
Issue number	5
DOIs	https://doi.org/10.1016/j.ijpara.2020.01.006
State	Published - May 2020
Externally published	Yes

Keywords

Apicomplexa
Bumped Kinase Inhibitor
Calcium-dependent Protein Kinases
Cryptosporidium
Gatekeeper
Neospora
Sarcocystis
Toxoplasma

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/j.ijpara.2020.01.006

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Choi, R., Hulverson, M. A., Huang, W., Vidadala, R. S. R., Whitman, G. R., Barrett, L. K., Schaefer, D. A., Betzer, D. P., Riggs, M. W., Doggett, J. S., Hemphill, A., Ortega-Mora, L. M., McCloskey, M. C., Arnold, S. L. M., Hackman, R. C., Marsh, K. C., Lynch, J. J., Freiberg, G. M., Leroy, B. E., ... Van Voorhis, W. C. (2020). Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned. International Journal for Parasitology, 50(5), 413-422. https://doi.org/10.1016/j.ijpara.2020.01.006

Choi, R, Hulverson, MA, Huang, W, Vidadala, RSR, Whitman, GR, Barrett, LK, Schaefer, DA, Betzer, DP, Riggs, MW, Doggett, JS, Hemphill, A, Ortega-Mora, LM, McCloskey, MC, Arnold, SLM, Hackman, RC, Marsh, KC, Lynch, JJ, Freiberg, GM, Leroy, BE, Kempf, DJ, Choy, RKM, de Hostos, EL, Maly, DJ, Fan, E, Ojo, KK & Van Voorhis, WC 2020, 'Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned', International Journal for Parasitology, vol. 50, no. 5, pp. 413-422. https://doi.org/10.1016/j.ijpara.2020.01.006

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abstract = "Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.",

keywords = "Apicomplexa, Bumped Kinase Inhibitor, Calcium-dependent Protein Kinases, Cryptosporidium, Gatekeeper, Neospora, Sarcocystis, Toxoplasma",

author = "Ryan Choi and Hulverson, {Matthew A.} and Wenlin Huang and Vidadala, {Rama S.R.} and Whitman, {Grant R.} and Barrett, {Lynn K.} and Schaefer, {Deborah A.} and Betzer, {Dana P.} and Riggs, {Michael W.} and Doggett, {J. Stone} and Andrew Hemphill and Ortega-Mora, {Luis Miguel} and McCloskey, {Molly C.} and Arnold, {Samuel L.M.} and Hackman, {Robert C.} and Marsh, {Kennan C.} and Lynch, {James J.} and Freiberg, {Gail M.} and Leroy, {Bruce E.} and Kempf, {Dale J.} and Choy, {Robert K.M.} and {de Hostos}, {Eugenio L.} and Maly, {Dustin J.} and Erkang Fan and Ojo, {Kayode K.} and {Van Voorhis}, {Wesley C.}",

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year = "2020",

month = may,

doi = "10.1016/j.ijpara.2020.01.006",

language = "English (US)",

volume = "50",

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AU - Choi, Ryan

AU - Hulverson, Matthew A.

AU - Huang, Wenlin

AU - Vidadala, Rama S.R.

AU - Whitman, Grant R.

AU - Barrett, Lynn K.

AU - Schaefer, Deborah A.

AU - Betzer, Dana P.

AU - Riggs, Michael W.

AU - Doggett, J. Stone

AU - Hemphill, Andrew

AU - Ortega-Mora, Luis Miguel

AU - McCloskey, Molly C.

AU - Arnold, Samuel L.M.

AU - Hackman, Robert C.

AU - Marsh, Kennan C.

AU - Lynch, James J.

AU - Freiberg, Gail M.

AU - Leroy, Bruce E.

AU - Kempf, Dale J.

AU - Choy, Robert K.M.

AU - de Hostos, Eugenio L.

AU - Maly, Dustin J.

AU - Fan, Erkang

AU - Ojo, Kayode K.

AU - Van Voorhis, Wesley C.

PY - 2020/5

Y1 - 2020/5

N2 - Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.

AB - Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.

KW - Apicomplexa

KW - Bumped Kinase Inhibitor

KW - Calcium-dependent Protein Kinases

KW - Cryptosporidium

KW - Gatekeeper

KW - Neospora

KW - Sarcocystis

KW - Toxoplasma

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SN - 0020-7519

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SP - 413

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JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 5

ER -

Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned

Abstract

Keywords

ASJC Scopus subject areas

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