Bronchoalveolar lavage as a research tool

Anthony S. Rose, Kenneth S. Knox

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Researchers over the past 40 years have utilized bronchoalveolar lavage (BAL) as a tool to help expand our knowledge of pulmonary medicine. Many reports have documented BAL as a safe procedure for research subjects. New technologies, such as flow cytometry, have provided much needed insight into the mechanisms behind several pulmonary diseases. The concept of the lung as an easily accessible mucosal site to monitor local immune responses and treatment effects is evolving. Future BAL research with human subjects, aided by new technology, will undoubtedly yield clinically relevant information regarding biomarkers of disease and new therapeutic targets.

Original languageEnglish (US)
Pages (from-to)561-573
Number of pages13
JournalSeminars in Respiratory and Critical Care Medicine
Issue number5
StatePublished - Oct 2007


  • Acellular
  • Bronchoalveolar lavage fluid
  • Cytometry
  • Immunology
  • Safety

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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