Broad range analysis of endocrine disruptors and pharmaceuticals using gas chromatography and liquid chromatography tandem mass spectrometry

Rebecca A. Trenholm; Brett J. Vanderford; Janie C. Holady; David J. Rexing; Shane A. Snyder

doi:10.1016/j.chemosphere.2006.07.004

Broad range analysis of endocrine disruptors and pharmaceuticals using gas chromatography and liquid chromatography tandem mass spectrometry

Rebecca A. Trenholm, Brett J. Vanderford, Janie C. Holady, David J. Rexing, Shane A. Snyder

Chemical and Environmental Engineering

Research output: Contribution to journal › Article › peer-review

198 Scopus citations

Abstract

Endocrine disrupting compounds (EDCs) and pharmaceuticals and personal care products (PPCPs) have been globally detected in impacted natural waters. The detection of trace quantities of EDCs and PPCPs in the environment is of great concern since some of these compounds have known physiological responses at low concentrations. EDCs can have a wide range of polarities, acidic and basic moieties, and exist in trace quantities, which often requires numerous complex extractions, large sample collection volumes, and multiple instrumental analyses. A comprehensive method has been developed allowing for the analysis of 58 potential EDCs in various water matrices using a single solid-phase extraction (SPE) of a 1 L sample with subsequent analyses using both gas chromatography and liquid chromatography, each coupled with tandem mass spectrometry (GC-MS/MS and LC-MS/MS). Instrument detection limits ranged between 0.12-7.5 pg with corresponding method reporting limits of 1-10 ng l^-1 in water. Recoveries for most compounds were between 50% and 112% with good reproducibility (RSD 6-22%).

Original language	English (US)
Pages (from-to)	1990-1998
Number of pages	9
Journal	Chemosphere
Volume	65
Issue number	11
DOIs	https://doi.org/10.1016/j.chemosphere.2006.07.004
State	Published - Dec 2006

Keywords

Endocrine disruptor
GC-MS/MS
LC-MS/MS
Solid-phase extraction

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
General Chemistry
Pollution
Health, Toxicology and Mutagenesis

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10.1016/j.chemosphere.2006.07.004

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title = "Broad range analysis of endocrine disruptors and pharmaceuticals using gas chromatography and liquid chromatography tandem mass spectrometry",

abstract = "Endocrine disrupting compounds (EDCs) and pharmaceuticals and personal care products (PPCPs) have been globally detected in impacted natural waters. The detection of trace quantities of EDCs and PPCPs in the environment is of great concern since some of these compounds have known physiological responses at low concentrations. EDCs can have a wide range of polarities, acidic and basic moieties, and exist in trace quantities, which often requires numerous complex extractions, large sample collection volumes, and multiple instrumental analyses. A comprehensive method has been developed allowing for the analysis of 58 potential EDCs in various water matrices using a single solid-phase extraction (SPE) of a 1 L sample with subsequent analyses using both gas chromatography and liquid chromatography, each coupled with tandem mass spectrometry (GC-MS/MS and LC-MS/MS). Instrument detection limits ranged between 0.12-7.5 pg with corresponding method reporting limits of 1-10 ng l-1 in water. Recoveries for most compounds were between 50% and 112% with good reproducibility (RSD 6-22%).",

keywords = "Endocrine disruptor, GC-MS/MS, LC-MS/MS, Solid-phase extraction",

author = "Trenholm, {Rebecca A.} and Vanderford, {Brett J.} and Holady, {Janie C.} and Rexing, {David J.} and Snyder, {Shane A.}",

note = "Funding Information: This work was supported in part by the American Water Works Association Research Foundation (AwwaRF) project# 2758 entitled “Evaluation of Conventional and Advanced Treatment Processes to Remove Endocrine Disruptors and Pharmaceutically Active Compounds”. The authors wish to acknowledge Dr. Paul Westerhoff of Arizona State University and Dr. Yeomin Yoon of CH2M Hill, for their grateful insight and contributions towards this investigation. The authors would also like to thank the staff at the Southern Nevada Water Authority for their assistance throughout this endeavor. ",

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AU - Vanderford, Brett J.

AU - Holady, Janie C.

AU - Rexing, David J.

AU - Snyder, Shane A.

N1 - Funding Information: This work was supported in part by the American Water Works Association Research Foundation (AwwaRF) project# 2758 entitled “Evaluation of Conventional and Advanced Treatment Processes to Remove Endocrine Disruptors and Pharmaceutically Active Compounds”. The authors wish to acknowledge Dr. Paul Westerhoff of Arizona State University and Dr. Yeomin Yoon of CH2M Hill, for their grateful insight and contributions towards this investigation. The authors would also like to thank the staff at the Southern Nevada Water Authority for their assistance throughout this endeavor.

PY - 2006/12

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N2 - Endocrine disrupting compounds (EDCs) and pharmaceuticals and personal care products (PPCPs) have been globally detected in impacted natural waters. The detection of trace quantities of EDCs and PPCPs in the environment is of great concern since some of these compounds have known physiological responses at low concentrations. EDCs can have a wide range of polarities, acidic and basic moieties, and exist in trace quantities, which often requires numerous complex extractions, large sample collection volumes, and multiple instrumental analyses. A comprehensive method has been developed allowing for the analysis of 58 potential EDCs in various water matrices using a single solid-phase extraction (SPE) of a 1 L sample with subsequent analyses using both gas chromatography and liquid chromatography, each coupled with tandem mass spectrometry (GC-MS/MS and LC-MS/MS). Instrument detection limits ranged between 0.12-7.5 pg with corresponding method reporting limits of 1-10 ng l-1 in water. Recoveries for most compounds were between 50% and 112% with good reproducibility (RSD 6-22%).

AB - Endocrine disrupting compounds (EDCs) and pharmaceuticals and personal care products (PPCPs) have been globally detected in impacted natural waters. The detection of trace quantities of EDCs and PPCPs in the environment is of great concern since some of these compounds have known physiological responses at low concentrations. EDCs can have a wide range of polarities, acidic and basic moieties, and exist in trace quantities, which often requires numerous complex extractions, large sample collection volumes, and multiple instrumental analyses. A comprehensive method has been developed allowing for the analysis of 58 potential EDCs in various water matrices using a single solid-phase extraction (SPE) of a 1 L sample with subsequent analyses using both gas chromatography and liquid chromatography, each coupled with tandem mass spectrometry (GC-MS/MS and LC-MS/MS). Instrument detection limits ranged between 0.12-7.5 pg with corresponding method reporting limits of 1-10 ng l-1 in water. Recoveries for most compounds were between 50% and 112% with good reproducibility (RSD 6-22%).

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Broad range analysis of endocrine disruptors and pharmaceuticals using gas chromatography and liquid chromatography tandem mass spectrometry

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