Brief report: Effect of intravenous methotrexate dose and infusion rate on neuropsychological function one year after diagnosis of acute lymphoblastic leukemia

Marissa E. Carey; Marilyn J. Hockenberry; Ida M. Moore; John J. Hutter; Kevin R. Krull; Alice Pasvogel; Kris L. Kaemingk

doi:10.1093/jpepsy/jsj114

Brief report: Effect of intravenous methotrexate dose and infusion rate on neuropsychological function one year after diagnosis of acute lymphoblastic leukemia

Marissa E. Carey, Marilyn J. Hockenberry, Ida M. Moore, John J. Hutter, Kevin R. Krull, Alice Pasvogel, Kris L. Kaemingk

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Objective: To compare the effects of two intravenous (IV) methotrexate (MTX) infusion protocols on cognitive function in children newly diagnosed with acute lymphoblastic leukemia (ALL). Methods: We compared 19 children treated with 1 g/m² of IV MTX over 24 hr (Group 1) to 13 children treated with 2 g/m² of IV MTX over 4 hr (Group 2) on measures of working memory, nonverbal, and verbal skills shortly after diagnosis (Time 1) and 1 year later (Time 2). Results: A significant Group×Time interaction was found for a composite measure of working memory with Group 2 declining from Time 1 to Time 2. Group 2 performed significantly worse than Group 1 on a composite measure of nonverbal skills at both time points. Conclusions: Findings suggest that difficulties in working memory and nonverbal skills may be evident during the first year of treatment for ALL and that severity may be dependent on IV MTX dose and/or infusion rate.

Original language	English (US)
Pages (from-to)	189-193
Number of pages	5
Journal	Journal of pediatric psychology
Volume	32
Issue number	2
DOIs	https://doi.org/10.1093/jpepsy/jsj114
State	Published - Mar 2007
Externally published	Yes

Keywords

Acute lymphoblastic leukemia
Chemotherapy
Methotrexate
Neuropsychology

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental and Educational Psychology

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10.1093/jpepsy/jsj114

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title = "Brief report: Effect of intravenous methotrexate dose and infusion rate on neuropsychological function one year after diagnosis of acute lymphoblastic leukemia",

abstract = "Objective: To compare the effects of two intravenous (IV) methotrexate (MTX) infusion protocols on cognitive function in children newly diagnosed with acute lymphoblastic leukemia (ALL). Methods: We compared 19 children treated with 1 g/m2 of IV MTX over 24 hr (Group 1) to 13 children treated with 2 g/m2 of IV MTX over 4 hr (Group 2) on measures of working memory, nonverbal, and verbal skills shortly after diagnosis (Time 1) and 1 year later (Time 2). Results: A significant Group×Time interaction was found for a composite measure of working memory with Group 2 declining from Time 1 to Time 2. Group 2 performed significantly worse than Group 1 on a composite measure of nonverbal skills at both time points. Conclusions: Findings suggest that difficulties in working memory and nonverbal skills may be evident during the first year of treatment for ALL and that severity may be dependent on IV MTX dose and/or infusion rate.",

keywords = "Acute lymphoblastic leukemia, Chemotherapy, Methotrexate, Neuropsychology",

author = "Carey, {Marissa E.} and Hockenberry, {Marilyn J.} and Moore, {Ida M.} and Hutter, {John J.} and Krull, {Kevin R.} and Alice Pasvogel and Kaemingk, {Kris L.}",

note = "Funding Information: This work was supported by the National Institutes of Health (HD37816 and NR04905). A portion of these data was presented at the 2nd Annual Conference of the American Psychosocial Oncology Society in Phoenix, Arizona (January 2005). The authors would like to thank Sheryl Reminger, PhD, and Marc Haut, PhD, for their feedback during manuscript preparation and Gerald Hobbs, PhD, for his help with statistical analyses.",

year = "2007",

month = mar,

doi = "10.1093/jpepsy/jsj114",

language = "English (US)",

volume = "32",

pages = "189--193",

journal = "Journal of pediatric psychology",

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T1 - Brief report

T2 - Effect of intravenous methotrexate dose and infusion rate on neuropsychological function one year after diagnosis of acute lymphoblastic leukemia

AU - Carey, Marissa E.

AU - Hockenberry, Marilyn J.

AU - Moore, Ida M.

AU - Hutter, John J.

AU - Krull, Kevin R.

AU - Pasvogel, Alice

AU - Kaemingk, Kris L.

N1 - Funding Information: This work was supported by the National Institutes of Health (HD37816 and NR04905). A portion of these data was presented at the 2nd Annual Conference of the American Psychosocial Oncology Society in Phoenix, Arizona (January 2005). The authors would like to thank Sheryl Reminger, PhD, and Marc Haut, PhD, for their feedback during manuscript preparation and Gerald Hobbs, PhD, for his help with statistical analyses.

PY - 2007/3

Y1 - 2007/3

N2 - Objective: To compare the effects of two intravenous (IV) methotrexate (MTX) infusion protocols on cognitive function in children newly diagnosed with acute lymphoblastic leukemia (ALL). Methods: We compared 19 children treated with 1 g/m2 of IV MTX over 24 hr (Group 1) to 13 children treated with 2 g/m2 of IV MTX over 4 hr (Group 2) on measures of working memory, nonverbal, and verbal skills shortly after diagnosis (Time 1) and 1 year later (Time 2). Results: A significant Group×Time interaction was found for a composite measure of working memory with Group 2 declining from Time 1 to Time 2. Group 2 performed significantly worse than Group 1 on a composite measure of nonverbal skills at both time points. Conclusions: Findings suggest that difficulties in working memory and nonverbal skills may be evident during the first year of treatment for ALL and that severity may be dependent on IV MTX dose and/or infusion rate.

AB - Objective: To compare the effects of two intravenous (IV) methotrexate (MTX) infusion protocols on cognitive function in children newly diagnosed with acute lymphoblastic leukemia (ALL). Methods: We compared 19 children treated with 1 g/m2 of IV MTX over 24 hr (Group 1) to 13 children treated with 2 g/m2 of IV MTX over 4 hr (Group 2) on measures of working memory, nonverbal, and verbal skills shortly after diagnosis (Time 1) and 1 year later (Time 2). Results: A significant Group×Time interaction was found for a composite measure of working memory with Group 2 declining from Time 1 to Time 2. Group 2 performed significantly worse than Group 1 on a composite measure of nonverbal skills at both time points. Conclusions: Findings suggest that difficulties in working memory and nonverbal skills may be evident during the first year of treatment for ALL and that severity may be dependent on IV MTX dose and/or infusion rate.

KW - Acute lymphoblastic leukemia

KW - Chemotherapy

KW - Methotrexate

KW - Neuropsychology

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Brief report: Effect of intravenous methotrexate dose and infusion rate on neuropsychological function one year after diagnosis of acute lymphoblastic leukemia

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