Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis

Annadurai Anandhan; Matthew Dodson; Cody J. Schmidlin; Pengfei Liu; Donna D. Zhang

doi:10.1016/j.chembiol.2020.03.011

Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis

Annadurai Anandhan
, Matthew Dodson
, Cody J. Schmidlin
, Pengfei Liu
, Donna D. Zhang

Research output: Contribution to journal › Review article › peer-review

363 Scopus citations

Abstract

In this review, Anandhan and Dodson et al. summarize key components of the ferroptosis cascade, including recent experimental evidence indicating a role for this novel mode of cell death in disease. The concept of targeting upstream mediators of ferroptosis, including the NRF2 pathway, to treat disease is also discussed.

Original language	English (US)
Pages (from-to)	436-447
Number of pages	12
Journal	Cell Chemical Biology
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.chembiol.2020.03.011
State	Published - Apr 16 2020

Keywords

NRF2
cancer
cardiovascular disease
cell death
diabetes
ferritinophagy
ferroptosis
iron
lipid peroxidation
neurodegeneration

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2020.03.011

Cite this

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title = "Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis",

abstract = "In this review, Anandhan and Dodson et al. summarize key components of the ferroptosis cascade, including recent experimental evidence indicating a role for this novel mode of cell death in disease. The concept of targeting upstream mediators of ferroptosis, including the NRF2 pathway, to treat disease is also discussed.",

keywords = "NRF2, cancer, cardiovascular disease, cell death, diabetes, ferritinophagy, ferroptosis, iron, lipid peroxidation, neurodegeneration",

author = "Annadurai Anandhan and Matthew Dodson and Schmidlin, \{Cody J.\} and Pengfei Liu and Zhang, \{Donna D.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = apr,

day = "16",

doi = "10.1016/j.chembiol.2020.03.011",

language = "English (US)",

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T2 - The Critical Role of NRF2 in Mediating Ferroptosis

AU - Anandhan, Annadurai

AU - Dodson, Matthew

AU - Schmidlin, Cody J.

AU - Liu, Pengfei

AU - Zhang, Donna D.

PY - 2020/4/16

Y1 - 2020/4/16

N2 - In this review, Anandhan and Dodson et al. summarize key components of the ferroptosis cascade, including recent experimental evidence indicating a role for this novel mode of cell death in disease. The concept of targeting upstream mediators of ferroptosis, including the NRF2 pathway, to treat disease is also discussed.

AB - In this review, Anandhan and Dodson et al. summarize key components of the ferroptosis cascade, including recent experimental evidence indicating a role for this novel mode of cell death in disease. The concept of targeting upstream mediators of ferroptosis, including the NRF2 pathway, to treat disease is also discussed.

KW - NRF2

KW - cancer

KW - cardiovascular disease

KW - cell death

KW - diabetes

KW - ferritinophagy

KW - ferroptosis

KW - iron

KW - lipid peroxidation

KW - neurodegeneration

UR - https://www.scopus.com/pages/publications/85082958645

UR - https://www.scopus.com/pages/publications/85082958645#tab=citedBy

U2 - 10.1016/j.chembiol.2020.03.011

DO - 10.1016/j.chembiol.2020.03.011

M3 - Review article

C2 - 32275864

AN - SCOPUS:85082958645

SN - 2451-9456

VL - 27

SP - 436

EP - 447

JO - Cell Chemical Biology

JF - Cell Chemical Biology

IS - 4

ER -

Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis

Abstract

Keywords

ASJC Scopus subject areas

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