Brain reserve, cognitive reserve, compensation, and maintenance: operationalization, validity, and mechanisms of cognitive resilience

Yaakov Stern; Carol A. Barnes; Cheryl Grady; Richard N. Jones; Naftali Raz

doi:10.1016/j.neurobiolaging.2019.03.022

Brain reserve, cognitive reserve, compensation, and maintenance: operationalization, validity, and mechanisms of cognitive resilience

Yaakov Stern, Carol A. Barnes, Cheryl Grady, Richard N. Jones, Naftali Raz

Research output: Contribution to journal › Article › peer-review

321 Scopus citations

Abstract

Significant individual differences in the trajectories of cognitive aging and in age-related changes of brain structure and function have been reported in the past half-century. In some individuals, significant pathological changes in the brain are observed in conjunction with relatively well-preserved cognitive performance. Multiple constructs have been invoked to explain this paradox of resilience, including brain reserve, cognitive reserve, brain maintenance, and compensation. The aim of this session of the Cognitive Aging Summit III was to examine the overlap and distinctions in definitions and measurement of these constructs, to discuss their neural and behavioral correlates and to propose plausible mechanisms of individual cognitive resilience in the face of typical age-related neural declines.

Original language	English (US)
Pages (from-to)	124-129
Number of pages	6
Journal	Neurobiology of Aging
Volume	83
DOIs	https://doi.org/10.1016/j.neurobiolaging.2019.03.022
State	Published - Nov 2019

Keywords

Animal models
Cognitive aging
Functional connectivity
MRI
Measurement

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2019.03.022

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AU - Jones, Richard N.

AU - Raz, Naftali

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KW - Measurement

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Brain reserve, cognitive reserve, compensation, and maintenance: operationalization, validity, and mechanisms of cognitive resilience

Abstract

Keywords

ASJC Scopus subject areas

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