Brain Ia antigens have a bone marrow origin

Jenny P.Y. Ting, Douglas F. Nixon, Leslie P. Weiner, Jeffrey A. Frelinger

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Our results, using radiation-induced bone marrow chimeras, demonstrate that the la antigen found in the brains of such animals is produced by cells having precursors in the bone marrow. These cells are not immediately blood borne since no IgM is detected in these brains. This rules out the obvious possibility of B-lymphocyte contamination as the source of la in the brain cell preparations. It thus appears that the central nervous system, like many other nonlymphoid organs, has a source of Ia-positive cells that are derived from bone marrow precursors.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
Issue number3
StatePublished - Mar 1983

ASJC Scopus subject areas

  • Immunology
  • Genetics


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