Brain Ia antigens have a bone marrow origin

Jenny P.Y. Ting; Douglas F. Nixon; Leslie P. Weiner; Jeffrey A. Frelinger

doi:10.1007/BF00364413

Brain Ia antigens have a bone marrow origin

Jenny P.Y. Ting, Douglas F. Nixon, Leslie P. Weiner, Jeffrey A. Frelinger

Immunobiology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Our results, using radiation-induced bone marrow chimeras, demonstrate that the la antigen found in the brains of such animals is produced by cells having precursors in the bone marrow. These cells are not immediately blood borne since no IgM is detected in these brains. This rules out the obvious possibility of B-lymphocyte contamination as the source of la in the brain cell preparations. It thus appears that the central nervous system, like many other nonlymphoid organs, has a source of Ia-positive cells that are derived from bone marrow precursors.

Original language	English (US)
Pages (from-to)	295-301
Number of pages	7
Journal	Immunogenetics
Volume	17
Issue number	3
DOIs	https://doi.org/10.1007/BF00364413
State	Published - Mar 1983

ASJC Scopus subject areas

Immunology
Genetics

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10.1007/BF00364413

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title = "Brain Ia antigens have a bone marrow origin",

abstract = "Our results, using radiation-induced bone marrow chimeras, demonstrate that the la antigen found in the brains of such animals is produced by cells having precursors in the bone marrow. These cells are not immediately blood borne since no IgM is detected in these brains. This rules out the obvious possibility of B-lymphocyte contamination as the source of la in the brain cell preparations. It thus appears that the central nervous system, like many other nonlymphoid organs, has a source of Ia-positive cells that are derived from bone marrow precursors.",

author = "Ting, {Jenny P.Y.} and Nixon, {Douglas F.} and Weiner, {Leslie P.} and Frelinger, {Jeffrey A.}",

year = "1983",

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T1 - Brain Ia antigens have a bone marrow origin

AU - Ting, Jenny P.Y.

AU - Nixon, Douglas F.

AU - Weiner, Leslie P.

AU - Frelinger, Jeffrey A.

PY - 1983/3

Y1 - 1983/3

N2 - Our results, using radiation-induced bone marrow chimeras, demonstrate that the la antigen found in the brains of such animals is produced by cells having precursors in the bone marrow. These cells are not immediately blood borne since no IgM is detected in these brains. This rules out the obvious possibility of B-lymphocyte contamination as the source of la in the brain cell preparations. It thus appears that the central nervous system, like many other nonlymphoid organs, has a source of Ia-positive cells that are derived from bone marrow precursors.

AB - Our results, using radiation-induced bone marrow chimeras, demonstrate that the la antigen found in the brains of such animals is produced by cells having precursors in the bone marrow. These cells are not immediately blood borne since no IgM is detected in these brains. This rules out the obvious possibility of B-lymphocyte contamination as the source of la in the brain cell preparations. It thus appears that the central nervous system, like many other nonlymphoid organs, has a source of Ia-positive cells that are derived from bone marrow precursors.

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JO - Immunogenetics

JF - Immunogenetics

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ER -

Brain Ia antigens have a bone marrow origin

Abstract

ASJC Scopus subject areas

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