Brain-Heart Interactions in Traumatic Brain Injury

Ayman El-Menyar, Abhishek Goyal, Rifat - Latifi, Hassan Al-Thani, William Frishman

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


The cardiovascular manifestations associated with nontraumatic head disorders are commonly known. Similar manifestations have been reported in patients with traumatic brain injury (TBI); however, the underlying mechanisms and impact on the patient's clinical outcomes are not well explored. The neurocardiac axis theory and neurogenic stunned myocardium phenomenon could partly explain the brain-heart link and interactions and can thus pave the way to a better understanding and management of TBI. Several observational retrospective studies have shown a promising role for beta-adrenergic blockers in patients with TBI in reducing the overall TBI-related mortality. However, several questions remain to be answered in clinical randomized-controlled trials, including population selection, beta blocker type, dosage, timing, and duration of therapy, while maintaining the optimal mean arterial pressure and cerebral perfusion pressure in patients with TBI.

Original languageEnglish (US)
Pages (from-to)279-288
Number of pages10
JournalCardiology in review
Issue number6
StatePublished - 2017


  • beta adrenergic blockers
  • biomarkers
  • brain injury
  • catecholamines
  • myocardial dysfunction
  • neurocardiac axis
  • neurogenic stunned myocardium
  • trauma
  • troponins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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