Bpur, the lyme disease spirochete's PUR domain protein: Identification as a transcriptional modulator and characterization of nucleic acid interactions

Brandon L. Jutras; Alicia M. Chenail; Dustin W. Carroll; M. Clarke Miller; Haining Zhu; Amy Bowman; Brian Stevenson

doi:10.1074/jbc.M113.491357

Bpur, the lyme disease spirochete's PUR domain protein: Identification as a transcriptional modulator and characterization of nucleic acid interactions

Brandon L. Jutras, Alicia M. Chenail, Dustin W. Carroll, M. Clarke Miller, Haining Zhu, Amy Bowman, Brian Stevenson

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background: Borrelia burgdorferi controls protein production during its infectious cycle. Results: Bpur was identified and shown to enhance effects of the erp transcriptional repressor, BpaB. Details of Bpur-nucleic acid interactions were obtained. Conclusion: Bpur participates in regulation of protein expression. Significance:Anew bacterial regulatory factor was identified and insight garnered on mechanisms by which Bpur interacts with nucleic acids.

Original language	English (US)
Pages (from-to)	26220-26234
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	288
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M113.491357
State	Published - Sep 6 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Bpur, the lyme disease spirochete's PUR domain protein: Identification as a transcriptional modulator and characterization of nucleic acid interactions. / Jutras, Brandon L.; Chenail, Alicia M.; Carroll, Dustin W. et al.
In: Journal of Biological Chemistry, Vol. 288, No. 36, 06.09.2013, p. 26220-26234.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background: Borrelia burgdorferi controls protein production during its infectious cycle. Results: Bpur was identified and shown to enhance effects of the erp transcriptional repressor, BpaB. Details of Bpur-nucleic acid interactions were obtained. Conclusion: Bpur participates in regulation of protein expression. Significance:Anew bacterial regulatory factor was identified and insight garnered on mechanisms by which Bpur interacts with nucleic acids.",

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AU - Carroll, Dustin W.

AU - Miller, M. Clarke

AU - Zhu, Haining

AU - Bowman, Amy

AU - Stevenson, Brian

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N2 - Background: Borrelia burgdorferi controls protein production during its infectious cycle. Results: Bpur was identified and shown to enhance effects of the erp transcriptional repressor, BpaB. Details of Bpur-nucleic acid interactions were obtained. Conclusion: Bpur participates in regulation of protein expression. Significance:Anew bacterial regulatory factor was identified and insight garnered on mechanisms by which Bpur interacts with nucleic acids.

AB - Background: Borrelia burgdorferi controls protein production during its infectious cycle. Results: Bpur was identified and shown to enhance effects of the erp transcriptional repressor, BpaB. Details of Bpur-nucleic acid interactions were obtained. Conclusion: Bpur participates in regulation of protein expression. Significance:Anew bacterial regulatory factor was identified and insight garnered on mechanisms by which Bpur interacts with nucleic acids.

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Bpur, the lyme disease spirochete's PUR domain protein: Identification as a transcriptional modulator and characterization of nucleic acid interactions

Abstract

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