Bone morphogenetic protein-9 increases the functional expression of organic anion transporting polypeptide 1a4 at the blood–brain barrier via the activin receptor-like kinase-1 receptor

Wazir Abdullahi, Hrvoje Brzica, Kathryn Ibbotson, Thomas P. Davis, Patrick T. Ronaldson

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Targeting uptake transporters such as organic anion transporting polypeptide 1a4 (Oatp1a4) at the blood–brain barrier (BBB) can facilitate central nervous system (CNS) drug delivery. Effective blood-to-brain drug transport via this strategy requires characterization of mechanisms that modulate BBB transporter expression and/or activity. Here, we show that activation of activin receptor-like kinase (ALK)-1 using bone morphogenetic protein (BMP)-9 increases Oatp1a4 protein expression in rat brain microvessels in vivo. These data indicate that targeting ALK1 signaling with BMP-9 modulates BBB Oatp1a4 expression, presenting a unique opportunity to optimize drug delivery and improve pharmacotherapy for CNS diseases.

Original languageEnglish (US)
Pages (from-to)2340-2345
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume37
Issue number7
DOIs
StatePublished - Jul 1 2017

Keywords

  • Basic science
  • blood–brain barrier
  • endothelium
  • pharmacology
  • vascular biology

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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